dc.date.accessioned | 2024-04-08T07:04:55Z | |
dc.date.created | 2024-02-28T08:40:55Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | Patel, Harsh K. Mori, Yuichi Hassan, Cesare Rizkala, Tommy Radadiya, Dhruvil K. Nathani, Piyush Srinivasan, Sachin Misawa, Masashi Maselli, Roberta Antonelli, Giulio Spadaccini, Marco Facciorusso, Antonio Khalaf, Kareem Lanza, Davide Bonanno, Giacomo Rex, Douglas K. Repici, Alessandro Sharma, Prateek . Lack of Effectiveness of Computer Aided Detection for Colorectal Neoplasia: A Systematic Review and Meta-Analysis of Nonrandomized Studies. Clinical Gastroenterology and Hepatology. 2024 | |
dc.identifier.uri | http://hdl.handle.net/10852/110477 | |
dc.description.abstract | Background and Aims
Benefits of computer-aided detection (CADe) in detecting colorectal neoplasia were shown in many randomized trials in which endoscopists’ behavior was strictly controlled. However, the effect of CADe on endoscopists’ performance in less-controlled setting is unclear. This systematic review and meta-analyses were aimed at clarifying benefits and harms of using CADe in real-world colonoscopy.
Methods
We searched MEDLINE, EMBASE, Cochrane, and Google Scholar from inception to August 20, 2023. We included nonrandomized studies that compared the effectiveness between CADe-assisted and standard colonoscopy. Two investigators independently extracted study data and quality. Pairwise meta-analysis was performed utilizing risk ratio for dichotomous variables and mean difference (MD) for continuous variables with a 95% confidence interval (CI).
Results
Eight studies were included, comprising 9782 patients (4569 with CADe and 5213 without CADe). Regarding benefits, there was a difference in neither adenoma detection rate (44% vs 38%; risk ratio, 1.11; 95% CI, 0.97 to 1.28) nor mean adenomas per colonoscopy (0.93 vs 0.79; MD, 0.14; 95% CI, –0.04 to 0.32) between CADe-assisted and standard colonoscopy, respectively. Regarding harms, there was no difference in the mean non-neoplastic lesions per colonoscopy (8 studies included for analysis; 0.52 vs 0.47; MD, 0.14; 95% CI, –0.07 to 0.34) and withdrawal time (6 studies included for analysis; 14.3 vs 13.4 minutes; MD, 0.8 minutes; 95% CI, –0.18 to 1.90). There was a substantial heterogeneity, and all outcomes were graded with a very low certainty of evidence.
Conclusion
CADe in colonoscopies neither improves the detection of colorectal neoplasia nor increases burden of colonoscopy in real-world, nonrandomized studies, questioning the generalizability of the results of randomized trials. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Lack of Effectiveness of Computer Aided Detection for Colorectal Neoplasia: A Systematic Review and Meta-Analysis of Nonrandomized Studies | |
dc.title.alternative | ENEngelskEnglishLack of Effectiveness of Computer Aided Detection for Colorectal Neoplasia: A Systematic Review and Meta-Analysis of Nonrandomized Studies | |
dc.type | Journal article | |
dc.creator.author | Patel, Harsh K. | |
dc.creator.author | Mori, Yuichi | |
dc.creator.author | Hassan, Cesare | |
dc.creator.author | Rizkala, Tommy | |
dc.creator.author | Radadiya, Dhruvil K. | |
dc.creator.author | Nathani, Piyush | |
dc.creator.author | Srinivasan, Sachin | |
dc.creator.author | Misawa, Masashi | |
dc.creator.author | Maselli, Roberta | |
dc.creator.author | Antonelli, Giulio | |
dc.creator.author | Spadaccini, Marco | |
dc.creator.author | Facciorusso, Antonio | |
dc.creator.author | Khalaf, Kareem | |
dc.creator.author | Lanza, Davide | |
dc.creator.author | Bonanno, Giacomo | |
dc.creator.author | Rex, Douglas K. | |
dc.creator.author | Repici, Alessandro | |
dc.creator.author | Sharma, Prateek | |
dc.date.embargoenddate | 2024-12-04 | |
cristin.unitcode | 185,0,0,0 | |
cristin.unitname | Universitetet i Oslo | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2250457 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical Gastroenterology and Hepatology&rft.volume=&rft.spage=&rft.date=2024 | |
dc.identifier.jtitle | Clinical Gastroenterology and Hepatology | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1016/j.cgh.2023.11.029 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1542-3565 | |
dc.type.version | AcceptedVersion | |