Preoperative CA19.9 level predicts lymph node metastasis in resectable adenocarcinoma of the head of the pancreas: A further plea for biological resectability criteria
dc.date.accessioned | 2024-04-05T15:23:38Z | |
dc.date.available | 2024-04-05T15:23:38Z | |
dc.date.created | 2024-02-14T13:49:16Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Coppola, Alessandro La Vaccara, Vincenzo Farolfi, Tommaso Asbun, Horacio J Boggi, Ugo Conlon, Kevin Edwin, Bjørn von Gohren Ferrone, Cristina Jonas, Eduard Kokudo, Norihiro Perez, Elena Martin Satoi, Sohei Sparrelid, Ernesto Stauffer, John A. Zerbi, Alessandro Takemura, Nobuyukil Lai, Quirino Almerey, Tariq Bernon, Marc Cammarata, Roberto Djoumi, Yasmine Gallagher, Tom Ghorbani, Poya Ginesini, Michael Hashimoto, Daisuke Kauffmann, Emanuele F. Kleive, Dyre Lluis, Nuria González, Rocio Maqueda Napoli, Niccolò Nappo, Gennaro Nebbia, Martina Ricchitelli, Simone Sahakyan, Mushegh Yamamoto, Tomohisa Coppola, Roberto Caputo, Damiano . Preoperative CA19.9 level predicts lymph node metastasis in resectable adenocarcinoma of the head of the pancreas: A further plea for biological resectability criteria. International Journal of Surgery (IJS). 2023 | |
dc.identifier.uri | http://hdl.handle.net/10852/110384 | |
dc.description.abstract | Introduction: Lymph-nodal involvement (N+) represents an adverse prognostic factor after pancreatoduodenectomy (PD) for pancreatic adenocarcinoma (PDAC). Preoperative diagnostic and staging modalities lack sensitivity for identifying N+. This study aimed to investigate preoperative CA19.9 in predicting the N+ stage in resectable-PDAC (R-PDAC). Methods: Patients included in a multi-institutional retrospective database of PDs performed for R-PDAC from January 2000 to June 2021 were analyzed. A preoperative laboratory value of CA19.9 >37 U/L was used in univariate and multivariate logistic regression analysis to determine a possible association with N+. Additionally, different cut-offs of CA19.9 related to the preoperative clinical T (cT) stage was assessed to evaluate the risk of N+. Results: A total of 2034 PDs from thirteen centers were included in the study. CA19.9>37 U/L was significantly associated with higher N+ at univariate and multivariate analysis (P<0.001). CA19.9 levels >37 U/L were associated with N+ in 75.9%, 81.3%, and 85.7% of patients, respectively, in cT1, cT2, and cT3 tumors and with higher cut-off values for all cT stages. Conclusion: Lymph nodal involvement is strongly related to preoperative CA19.9 levels. Specially in patients staged as cT3 the CA 19.9 could represent a valid and easy tool to suspect nodal involvement. Due to these findings, R-PDAC patients with elevated CA19.9 values should be considered in a more biologically advanced stage. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Preoperative CA19.9 level predicts lymph node metastasis in resectable adenocarcinoma of the head of the pancreas: A further plea for biological resectability criteria | |
dc.title.alternative | ENEngelskEnglishPreoperative CA19.9 level predicts lymph node metastasis in resectable adenocarcinoma of the head of the pancreas: A further plea for biological resectability criteria | |
dc.type | Journal article | |
dc.creator.author | Coppola, Alessandro | |
dc.creator.author | La Vaccara, Vincenzo | |
dc.creator.author | Farolfi, Tommaso | |
dc.creator.author | Asbun, Horacio J | |
dc.creator.author | Boggi, Ugo | |
dc.creator.author | Conlon, Kevin | |
dc.creator.author | Edwin, Bjørn von Gohren | |
dc.creator.author | Ferrone, Cristina | |
dc.creator.author | Jonas, Eduard | |
dc.creator.author | Kokudo, Norihiro | |
dc.creator.author | Perez, Elena Martin | |
dc.creator.author | Satoi, Sohei | |
dc.creator.author | Sparrelid, Ernesto | |
dc.creator.author | Stauffer, John A. | |
dc.creator.author | Zerbi, Alessandro | |
dc.creator.author | Takemura, Nobuyukil | |
dc.creator.author | Lai, Quirino | |
dc.creator.author | Almerey, Tariq | |
dc.creator.author | Bernon, Marc | |
dc.creator.author | Cammarata, Roberto | |
dc.creator.author | Djoumi, Yasmine | |
dc.creator.author | Gallagher, Tom | |
dc.creator.author | Ghorbani, Poya | |
dc.creator.author | Ginesini, Michael | |
dc.creator.author | Hashimoto, Daisuke | |
dc.creator.author | Kauffmann, Emanuele F. | |
dc.creator.author | Kleive, Dyre | |
dc.creator.author | Lluis, Nuria | |
dc.creator.author | González, Rocio Maqueda | |
dc.creator.author | Napoli, Niccolò | |
dc.creator.author | Nappo, Gennaro | |
dc.creator.author | Nebbia, Martina | |
dc.creator.author | Ricchitelli, Simone | |
dc.creator.author | Sahakyan, Mushegh | |
dc.creator.author | Yamamoto, Tomohisa | |
dc.creator.author | Coppola, Roberto | |
dc.creator.author | Caputo, Damiano | |
cristin.unitcode | 185,53,2,17 | |
cristin.unitname | Intervensjonssenteret | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2245971 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International Journal of Surgery (IJS)&rft.volume=&rft.spage=&rft.date=2023 | |
dc.identifier.jtitle | International Journal of Surgery (IJS) | |
dc.identifier.pagecount | 29 | |
dc.identifier.doi | https://doi.org/10.1097/JS9.0000000000000773 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1743-9191 | |
dc.type.version | AcceptedVersion |
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