dc.date.accessioned | 2024-04-04T15:25:44Z | |
dc.date.created | 2024-02-15T11:00:35Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Gerber, Lucie Claire Lola Resseguier, Julien Alain Andre Helle-Valle, Tellef Farhat, Elie Nilsson, Göran Erik Nilsson, Sjannie Lefevre . Expression of prolyl hydroxylase domains, the upstream regulators of HIF, in the brain of the anoxia-tolerant crucian carp during anoxia-reoxygenation. American Journal of Physiology. Regulatory Integrative and Comparative Physiology. 2023, 326(2), R184-R195 | |
dc.identifier.uri | http://hdl.handle.net/10852/110351 | |
dc.description.abstract | We report a profound upregulation of most egln paralog mRNA levels in anoxia and upon reoxygenation, with egln3ii showing the largest, a 17-fold increase, and highest relative mRNA abundance. The relative abundance of prolyl hydroxylase domain (PHD) proteins was maintained during anoxia and increased at reoxygenation. PHD immunoreactivity was localized to axonal branches with region-specific changes during anoxia-reoxygenation. These dynamic and regional changes in crucian carp, champion of anoxia tolerance, are most likely adaptive and call for further mechanistic studies. | |
dc.language | EN | |
dc.publisher | HighWire Press | |
dc.title | Expression of prolyl hydroxylase domains, the upstream regulators of HIF, in the brain of the anoxia-tolerant crucian carp during anoxia-reoxygenation | |
dc.title.alternative | ENEngelskEnglishExpression of prolyl hydroxylase domains, the upstream regulators of HIF, in the brain of the anoxia-tolerant crucian carp during anoxia-reoxygenation | |
dc.type | Journal article | |
dc.creator.author | Gerber, Lucie Claire Lola | |
dc.creator.author | Resseguier, Julien Alain Andre | |
dc.creator.author | Helle-Valle, Tellef | |
dc.creator.author | Farhat, Elie | |
dc.creator.author | Nilsson, Göran Erik | |
dc.creator.author | Nilsson, Sjannie Lefevre | |
dc.date.embargoenddate | 2025-01-29 | |
cristin.unitcode | 185,15,29,30 | |
cristin.unitname | Seksjon for fysiologi og cellebiologi | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2246315 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American Journal of Physiology. Regulatory Integrative and Comparative Physiology&rft.volume=326&rft.spage=R184&rft.date=2023 | |
dc.identifier.jtitle | American Journal of Physiology. Regulatory Integrative and Comparative Physiology | |
dc.identifier.volume | 326 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | R184 | |
dc.identifier.endpage | R195 | |
dc.identifier.doi | https://doi.org/10.1152/ajpregu.00211.2023 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0363-6119 | |
dc.type.version | AcceptedVersion | |