dc.date.accessioned | 2024-03-04T17:43:38Z | |
dc.date.available | 2024-03-04T17:43:38Z | |
dc.date.created | 2023-11-03T09:56:28Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Pentz, Atle Bråthen Timpe, Clara Marie Fides Normann, Elizabeth Marie Slapø, Nora Berz Melle, Ingrid Lagerberg, Trine Vik Steen, Nils Eiel Westlye, Lars Tjelta Jönsson, Erik Gunnar Haukvik, Unn Kristin Hansen Moberget, Torgeir Andreassen, Ole Elvsåshagen, Torbjørn . Mismatch negativity in schizophrenia spectrum and bipolar disorders: Group and sex differences and associations with symptom severity. Schizophrenia Research. 2023, 261, 80-93 | |
dc.identifier.uri | http://hdl.handle.net/10852/108995 | |
dc.description.abstract | Objective
Research increasingly implicates glutamatergic dysfunction in the pathophysiologies of psychotic disorders. Auditory mismatch negativity (MMN) is an electroencephalography (EEG) waveform linked to glutamatergic neurotransmission and is consistently attenuated in schizophrenia (SCZ). MMN consists of two subcomponents, the repetition positivity (RP) and deviant negativity (DN) possibly reflecting different neural mechanisms. However, whether MMN reduction is present across different psychotic disorders, linked to distinct symptom clusters, or related to sex remain to be clarified.
Methods
Four hundred participants including healthy controls (HCs; n = 296) and individuals with SCZ (n = 39), bipolar disorder (BD) BD typeI (n = 35), or BD type II (n = 30) underwent a roving MMN paradigm and clinical evaluation. MMN, RP and DN as well their memory traces were recorded at the FCZ electrode. Analyses of variance and linear regression models were used both transdiagnostically and within clinical groups.
Results
MMN was reduced in SCZ compared to BD (p = 0.006, d = 0.55) and to HCs (p < 0.001, d = 0.63). There was a significant group × sex interaction (p < 0.003) and the MMN impairment was only detected in males with SCZ. MMN amplitude correlated positively with Positive and Negative Syndrome Scale total score and negatively with Global Assessment of Functioning Scale score. The deviant negativity was impaired in males with SCZ. No group differences in memory trace indices of the MMN, DN, or RP.
Conclusion
MMN was attenuated in SCZ and correlated with greater severity of psychotic symptoms and lower level of functioning. Our results may indicate sex-dependent differences of glutamatergic function in SCZ. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Mismatch negativity in schizophrenia spectrum and bipolar disorders: Group and sex differences and associations with symptom severity | |
dc.title.alternative | ENEngelskEnglishMismatch negativity in schizophrenia spectrum and bipolar disorders: Group and sex differences and associations with symptom severity | |
dc.type | Journal article | |
dc.creator.author | Pentz, Atle Bråthen | |
dc.creator.author | Timpe, Clara Marie Fides | |
dc.creator.author | Normann, Elizabeth Marie | |
dc.creator.author | Slapø, Nora Berz | |
dc.creator.author | Melle, Ingrid | |
dc.creator.author | Lagerberg, Trine Vik | |
dc.creator.author | Steen, Nils Eiel | |
dc.creator.author | Westlye, Lars Tjelta | |
dc.creator.author | Jönsson, Erik Gunnar | |
dc.creator.author | Haukvik, Unn Kristin Hansen | |
dc.creator.author | Moberget, Torgeir | |
dc.creator.author | Andreassen, Ole | |
dc.creator.author | Elvsåshagen, Torbjørn | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | Senter for presisjonspsykiatri | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2191792 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Schizophrenia Research&rft.volume=261&rft.spage=80&rft.date=2023 | |
dc.identifier.jtitle | Schizophrenia Research | |
dc.identifier.volume | 261 | |
dc.identifier.startpage | 80 | |
dc.identifier.endpage | 93 | |
dc.identifier.doi | https://doi.org/10.1016/j.schres.2023.09.012 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0920-9964 | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/223273 | |