dc.date.accessioned | 2024-02-29T18:02:18Z | |
dc.date.available | 2024-02-29T18:02:18Z | |
dc.date.created | 2023-11-16T08:24:05Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Ulnes, Maria Albrektsson, Henrik Størdal, Ketil Saalman, Robert Ludvigsson, Jonas F. Mårild, Karl Staffan . Lack of Follow-Up for Celiac Disease During Childhood Not Associated With Poor Health Outcomes: A Regional Swedish Cohort Study. Journal of Pediatric Gastroenterology and Nutrition - JPGN. 2023, 77(5), 640-647 | |
dc.identifier.uri | http://hdl.handle.net/10852/108808 | |
dc.description.abstract | Objectives:
The objective of the study is to examine the association between the lack of follow-up for celiac disease (CD) during childhood and dietary adherence, disease remission, and health-related quality of life (HRQoL).
Methods:
We invited 243 randomly selected children diagnosed with CD in 2013–2018 in Gothenburg, Sweden, and 162 consented to participate (67%). We retrieved information on clinical follow-up and current wellbeing using medical and laboratory records data, as well as validated questionnaires on symptoms of CD, dietary adherence, and HRQoL. We analyzed tissue-transglutaminase antibodies (tTGA) as a measure of disease remission. We defined lack of follow-up as no CD-related physician/dietician-led visit or measurement of tTGA over the past 24 months of study enrollment.
Results:
The mean age at study enrolment was 12.7 (range 7.8–18.2) years. Out of 162 children with an average disease duration of 5.3 (range 2.3–8.8) years, 23 (14%) lacked follow-up. tTGA had normalized in 94% [95% confidence interval (CI) = 71%–100%] of children without follow-up versus 91% (95% CI: 85%–95%) of children with continued follow-up. Of children without follow-up, 65% (95% CI: 38%–86%) reported a dietary adherence score indicating very good adherence, versus 72% (95% CI: 63%–80%) of those with continued follow-up. Also, lack of follow-up was not significantly associated with growth, symptom scores, or HRQoL.
Conclusions:
In this regional cohort study of mostly older children and adolescents, lack of follow-up for CD was not significantly linked to dietary adherence, disease remission, or HRQoL. How these results hold in larger, unselected samples with longer follow-up, including transition to adult care, warrants further study. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Lack of Follow-Up for Celiac Disease During Childhood Not Associated With Poor Health Outcomes: A Regional Swedish Cohort Study | |
dc.title.alternative | ENEngelskEnglishLack of Follow-Up for Celiac Disease During Childhood Not Associated With Poor Health Outcomes: A Regional Swedish Cohort Study | |
dc.type | Journal article | |
dc.creator.author | Ulnes, Maria | |
dc.creator.author | Albrektsson, Henrik | |
dc.creator.author | Størdal, Ketil | |
dc.creator.author | Saalman, Robert | |
dc.creator.author | Ludvigsson, Jonas F. | |
dc.creator.author | Mårild, Karl Staffan | |
cristin.unitcode | 185,53,46,1 | |
cristin.unitname | Forskningsleder BAR | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2197374 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Pediatric Gastroenterology and Nutrition - JPGN&rft.volume=77&rft.spage=640&rft.date=2023 | |
dc.identifier.jtitle | Journal of Pediatric Gastroenterology and Nutrition - JPGN | |
dc.identifier.volume | 77 | |
dc.identifier.issue | 5 | |
dc.identifier.startpage | 640 | |
dc.identifier.endpage | 647 | |
dc.identifier.doi | https://doi.org/10.1097/MPG.0000000000003911 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0277-2116 | |
dc.type.version | PublishedVersion | |