dc.date.accessioned | 2024-02-23T02:03:58Z | |
dc.date.available | 2024-02-23T02:03:58Z | |
dc.date.created | 2023-10-02T12:41:03Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Saadi, Saadia Maryam Cali, Elisa Khalid, Lubaba Bintee Yousaf, Hammad Zafar, Ghazala Khan, Haq Nawaz Sher, Muhammad Vona, Barbara Abdullah, Uzma Malik, Naveed Altaf Klar, Joakim Efthymiou, Stephanie Dahl, Niklas Houlden, Henry Toft, Mathias Baig, Shahid Mahmood Fatima, Ambrin Iqbal, Zafar . Genetic Investigation of Consanguineous Pakistani Families Segregating Rare Spinocerebellar Disorders. Genes. 2023, 14(7) | |
dc.identifier.uri | http://hdl.handle.net/10852/108579 | |
dc.description.abstract | Spinocerebellar disorders are a vast group of rare neurogenetic conditions, generally characterized by overlapping clinical symptoms including progressive cerebellar ataxia, spastic paraparesis, cognitive deficiencies, skeletal/muscular and ocular abnormalities. The objective of the present study is to identify the underlying genetic causes of the rare spinocerebellar disorders in the Pakistani population. Herein, nine consanguineous families presenting different spinocerebellar phenotypes have been investigated using whole exome sequencing. Sanger sequencing was performed for segregation analysis in all the available individuals of each family. The molecular analysis of these families identified six novel pathogenic/likely pathogenic variants; ZFYVE26: c.1093del, SACS: c.1201C>T, BICD2: c.2156A>T, ALS2: c.2171-3T>G, ALS2: c.3145T>A, and B4GALNT1: c.334_335dup, and three already reported pathogenic variants; FA2H: c.159_176del, APTX: c.689T>G, and SETX: c.5308_5311del. The clinical features of all patients in each family are concurrent with the already reported cases. Hence, the current study expands the mutation spectrum of rare spinocerebellar disorders and implies the usefulness of next-generation sequencing in combination with clinical investigation for better diagnosis of these overlapping phenotypes. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Genetic Investigation of Consanguineous Pakistani Families Segregating Rare Spinocerebellar Disorders | |
dc.title.alternative | ENEngelskEnglishGenetic Investigation of Consanguineous Pakistani Families Segregating Rare Spinocerebellar Disorders | |
dc.type | Journal article | |
dc.creator.author | Saadi, Saadia Maryam | |
dc.creator.author | Cali, Elisa | |
dc.creator.author | Khalid, Lubaba Bintee | |
dc.creator.author | Yousaf, Hammad | |
dc.creator.author | Zafar, Ghazala | |
dc.creator.author | Khan, Haq Nawaz | |
dc.creator.author | Sher, Muhammad | |
dc.creator.author | Vona, Barbara | |
dc.creator.author | Abdullah, Uzma | |
dc.creator.author | Malik, Naveed Altaf | |
dc.creator.author | Klar, Joakim | |
dc.creator.author | Efthymiou, Stephanie | |
dc.creator.author | Dahl, Niklas | |
dc.creator.author | Houlden, Henry | |
dc.creator.author | Toft, Mathias | |
dc.creator.author | Baig, Shahid Mahmood | |
dc.creator.author | Fatima, Ambrin | |
dc.creator.author | Iqbal, Zafar | |
cristin.unitcode | 185,53,42,13 | |
cristin.unitname | Nevrologisk avdeling | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2180914 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Genes&rft.volume=14&rft.spage=&rft.date=2023 | |
dc.identifier.jtitle | Genes | |
dc.identifier.volume | 14 | |
dc.identifier.issue | 7 | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.3390/genes14071404 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2073-4425 | |
dc.type.version | PublishedVersion | |
cristin.articleid | 1404 | |