dc.date.accessioned | 2024-02-22T21:55:40Z | |
dc.date.available | 2024-02-22T21:55:40Z | |
dc.date.created | 2023-12-18T19:53:22Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Kirkels, Feddo Pieter Rootwelt-Norberg, Christine Bosman, Laurens P. Aabel, Eivind Westrum Muller, Steven A. Castrini, Anna Isotta Taha, Karim van Osta, Nick Lie, Øyvind Haugen Asselbergs, Folkert W. Lumens, Joost te Riele, Anneline S.J.M. Hasselberg, Nina Eide Cramer, Maarten J. Haugaa, Kristina Ingrid Helena Hermann Teske, Arco J. . The added value of abnormal regional myocardial function for risk prediction in arrhythmogenic right ventricular cardiomyopathy. European Heart Journal-Cardiovascular Imaging. 2023, 24(12), 1710-1718 | |
dc.identifier.uri | http://hdl.handle.net/10852/108561 | |
dc.description.abstract | Abstract
Aims
A risk calculator for individualized prediction of first-time sustained ventricular arrhythmia (VA) in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients has recently been developed and validated (www.ARVCrisk.com). This study aimed to investigate whether regional functional abnormalities, measured by echocardiographic deformation imaging, can provide additional prognostic value.
Methods and results
From two referral centres, 150 consecutive patients with a definite ARVC diagnosis, no prior sustained VA, and an echocardiogram suitable for deformation analysis were included (aged 41 ± 17 years, 50% female). During a median follow-up of 6.3 (interquartile range 3.1–9.8) years, 37 (25%) experienced a first-time sustained VA. All tested left and right ventricular (LV and RV) deformation parameters were univariate predictors for first-time VA. While LV function did not add predictive value in multivariate analysis, two RV deformation parameters did; RV free wall longitudinal strain and regional RV deformation patterns remained independent predictors after adjusting for the calculator-predicted risk [hazard ratio 1.07 (95% CI 1.02–1.11); P = 0.004 and 4.45 (95% CI 1.07–18.57); P = 0.040, respectively] and improved its discriminative value (from C-statistic 0.78 to 0.82 in both; Akaike information criterion change > 2). Importantly, all patients who experienced VA within 5 years from the echocardiographic assessment had abnormal regional RV deformation patterns at baseline.
Conclusions
This study showed that regional functional abnormalities measured by echocardiographic deformation imaging can further refine personalized arrhythmic risk prediction when added to the ARVC risk calculator. The excellent negative predictive value of normal RV deformation could support clinicians considering the timing of implantable cardioverter defibrillator implantation in patients with intermediate arrhythmic risk. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | The added value of abnormal regional myocardial function for risk prediction in arrhythmogenic right ventricular cardiomyopathy | |
dc.title.alternative | ENEngelskEnglishThe added value of abnormal regional myocardial function for risk prediction in arrhythmogenic right ventricular cardiomyopathy | |
dc.type | Journal article | |
dc.creator.author | Kirkels, Feddo Pieter | |
dc.creator.author | Rootwelt-Norberg, Christine | |
dc.creator.author | Bosman, Laurens P. | |
dc.creator.author | Aabel, Eivind Westrum | |
dc.creator.author | Muller, Steven A. | |
dc.creator.author | Castrini, Anna Isotta | |
dc.creator.author | Taha, Karim | |
dc.creator.author | van Osta, Nick | |
dc.creator.author | Lie, Øyvind Haugen | |
dc.creator.author | Asselbergs, Folkert W. | |
dc.creator.author | Lumens, Joost | |
dc.creator.author | te Riele, Anneline S.J.M. | |
dc.creator.author | Hasselberg, Nina Eide | |
dc.creator.author | Cramer, Maarten J. | |
dc.creator.author | Haugaa, Kristina Ingrid Helena Hermann | |
dc.creator.author | Teske, Arco J. | |
cristin.unitcode | 185,53,15,13 | |
cristin.unitname | Kardiologisk avdeling | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2215173 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European Heart Journal-Cardiovascular Imaging&rft.volume=24&rft.spage=1710&rft.date=2023 | |
dc.identifier.jtitle | European Heart Journal-Cardiovascular Imaging | |
dc.identifier.volume | 24 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 1710 | |
dc.identifier.endpage | 1718 | |
dc.identifier.doi | https://doi.org/10.1093/ehjci/jead174 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2047-2404 | |
dc.type.version | PublishedVersion | |