dc.date.accessioned | 2024-02-20T18:22:55Z | |
dc.date.available | 2024-02-20T18:22:55Z | |
dc.date.created | 2023-11-14T07:55:04Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Eltokhi, Ahmed Bertocchi, Ilaria Rozov, Andrei Jensen, Vidar Borchardt, Thilo Taylor, Amy Proenca, Catia C. Rawlins, John Nick P. Bannerman, David M. Sprengel, Rolf . Distinct effects of AMPAR subunit depletion on spatial memory. iScience. 2023, 26(11) | |
dc.identifier.uri | http://hdl.handle.net/10852/108372 | |
dc.description.abstract | Pharmacological studies established a role for AMPARs in the mammalian forebrain in spatial memory performance. Here we generated global GluA1/3 double knockout mice (Gria1/3−/−) and conditional knockouts lacking GluA1 and GluA3 AMPAR subunits specifically from principal cells across the forebrain (Gria1/3ΔFb). In both models, loss of GluA1 and GluA3 resulted in reduced hippocampal GluA2 and increased levels of the NMDAR subunit GluN2A. Electrically-evoked AMPAR-mediated EPSPs were greatly diminished, and there was an absence of tetanus-induced LTP. Gria1/3−/− mice showed premature mortality. Gria1/3ΔFb mice were viable, and their memory performance could be analyzed. In the Morris water maze (MWM), Gria1/3ΔFb mice showed profound long-term memory deficits, in marked contrast to the normal MWM learning previously seen in single Gria1−/− and Gria3−/− knockout mice. Our results suggest a redundancy of function within the pool of available ionotropic glutamate receptors for long-term spatial memory performance. | |
dc.language | EN | |
dc.publisher | Cell Press | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Distinct effects of AMPAR subunit depletion on spatial memory | |
dc.title.alternative | ENEngelskEnglishDistinct effects of AMPAR subunit depletion on spatial memory | |
dc.type | Journal article | |
dc.creator.author | Eltokhi, Ahmed | |
dc.creator.author | Bertocchi, Ilaria | |
dc.creator.author | Rozov, Andrei | |
dc.creator.author | Jensen, Vidar | |
dc.creator.author | Borchardt, Thilo | |
dc.creator.author | Taylor, Amy | |
dc.creator.author | Proenca, Catia C. | |
dc.creator.author | Rawlins, John Nick P. | |
dc.creator.author | Bannerman, David M. | |
dc.creator.author | Sprengel, Rolf | |
cristin.unitcode | 185,51,12,30 | |
cristin.unitname | Seksjon for anatomi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2196179 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=iScience&rft.volume=26&rft.spage=&rft.date=2023 | |
dc.identifier.jtitle | iScience | |
dc.identifier.volume | 26 | |
dc.identifier.issue | 11 | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1016/j.isci.2023.108116 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2589-0042 | |
dc.type.version | PublishedVersion | |
cristin.articleid | 108116 | |