dc.date.accessioned | 2024-02-14T17:46:20Z | |
dc.date.available | 2024-02-14T17:46:20Z | |
dc.date.created | 2023-06-01T13:19:28Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Tonkin-Hill, Gerry Gladstone, Rebecca Ashley Pöntinen, Anna Kaarina Alonso, Sergio Arredondo Bentley, Stephen D. Corander, Jukka . Robust analysis of prokaryotic pangenome gene gain and loss rates with Panstripe. Genome Research. 2023, 33(1), 129-140 | |
dc.identifier.uri | http://hdl.handle.net/10852/108042 | |
dc.description.abstract | Horizontal gene transfer (HGT) plays a critical role in the evolution and diversification of many microbial species. The resulting dynamics of gene gain and loss can have important implications for the development of antibiotic resistance and the design of vaccine and drug interventions. Methods for the analysis of gene presence/absence patterns typically do not account for errors introduced in the automated annotation and clustering of gene sequences. In particular, methods adapted from ecological studies, including the pangenome gene accumulation curve, can be misleading as they may reflect the underlying diversity in the temporal sampling of genomes rather than a difference in the dynamics of HGT. Here, we introduce Panstripe, a method based on generalized linear regression that is robust to population structure, sampling bias, and errors in the predicted presence/absence of genes. We show using simulations that Panstripe can effectively identify differences in the rate and number of genes involved in HGT events, and illustrate its capability by analyzing several diverse bacterial genome data sets representing major human pathogens. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Robust analysis of prokaryotic pangenome gene gain and loss rates with Panstripe | |
dc.title.alternative | ENEngelskEnglishRobust analysis of prokaryotic pangenome gene gain and loss rates with Panstripe | |
dc.type | Journal article | |
dc.creator.author | Tonkin-Hill, Gerry | |
dc.creator.author | Gladstone, Rebecca Ashley | |
dc.creator.author | Pöntinen, Anna Kaarina | |
dc.creator.author | Alonso, Sergio Arredondo | |
dc.creator.author | Bentley, Stephen D. | |
dc.creator.author | Corander, Jukka | |
cristin.unitcode | 185,51,15,3 | |
cristin.unitname | Probabilistisk inferens laboratorium | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2150833 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Genome Research&rft.volume=33&rft.spage=129&rft.date=2023 | |
dc.identifier.jtitle | Genome Research | |
dc.identifier.volume | 33 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 129 | |
dc.identifier.endpage | 140 | |
dc.identifier.doi | https://doi.org/10.1101/gr.277340.122 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1088-9051 | |
dc.type.version | PublishedVersion | |