dc.date.accessioned | 2024-02-07T16:42:26Z | |
dc.date.available | 2024-02-07T16:42:26Z | |
dc.date.created | 2023-06-15T13:56:19Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Maxwell, Michael J. Thekkedam, Chris Lamboley, Cedric Chin, Yanni K.-Y. Crawford, Theo Smith, Jennifer J. Liu, Junyu Jia, Xinying Vetter, Irina Laver, Derek R. Launikonis, Bradley S. Dulhunty, Angela Undheim, Eivind Andreas Baste Mobli, Mehdi . A bivalent remipede toxin promotes calcium release via ryanodine receptor activation. Nature Communications. 2023, 14(1), 1-13 | |
dc.identifier.uri | http://hdl.handle.net/10852/107667 | |
dc.description.abstract | Abstract Multivalent ligands of ion channels have proven to be both very rare and highly valuable in yielding unique insights into channel structure and pharmacology. Here, we describe a bivalent peptide from the venom of Xibalbanus tulumensis , a troglobitic arthropod from the enigmatic class Remipedia, that causes persistent calcium release by activation of ion channels involved in muscle contraction. The high-resolution solution structure of φ-Xibalbin3-Xt3a reveals a tandem repeat arrangement of inhibitor-cysteine knot (ICK) domains previously only found in spider venoms. The individual repeats of Xt3a share sequence similarity with a family of scorpion toxins that target ryanodine receptors (RyR). Single-channel electrophysiology and quantification of released Ca 2+ stores within skinned muscle fibers confirm Xt3a as a bivalent RyR modulator. Our results reveal convergent evolution of RyR targeting toxins in remipede and scorpion venoms, while the tandem-ICK repeat architecture is an evolutionary innovation that is convergent with toxins from spider venoms. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | A bivalent remipede toxin promotes calcium release via ryanodine receptor activation | |
dc.title.alternative | ENEngelskEnglishA bivalent remipede toxin promotes calcium release via ryanodine receptor activation | |
dc.type | Journal article | |
dc.creator.author | Maxwell, Michael J. | |
dc.creator.author | Thekkedam, Chris | |
dc.creator.author | Lamboley, Cedric | |
dc.creator.author | Chin, Yanni K.-Y. | |
dc.creator.author | Crawford, Theo | |
dc.creator.author | Smith, Jennifer J. | |
dc.creator.author | Liu, Junyu | |
dc.creator.author | Jia, Xinying | |
dc.creator.author | Vetter, Irina | |
dc.creator.author | Laver, Derek R. | |
dc.creator.author | Launikonis, Bradley S. | |
dc.creator.author | Dulhunty, Angela | |
dc.creator.author | Undheim, Eivind Andreas Baste | |
dc.creator.author | Mobli, Mehdi | |
cristin.unitcode | 185,15,29,50 | |
cristin.unitname | Centre for Ecological and Evolutionary Synthesis | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2154909 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=14&rft.spage=1&rft.date=2023 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 14 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.1038/s41467-023-36579-w | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.type.version | PublishedVersion | |
cristin.articleid | 1036 | |
dc.relation.project | NFR/287462 | |