dc.date.accessioned | 2024-02-05T17:32:27Z | |
dc.date.available | 2024-06-11T22:46:00Z | |
dc.date.created | 2023-06-30T13:01:59Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Hovda, Tone Larsen, Marthe Romundstad, Linda Sahlberg, Guro Kristine Kleivi Hofvind, Solveig Sand-Hanssen . Breast cancer missed at screening; hindsight or mistakes?. European Journal of Radiology. 2023, 165 | |
dc.identifier.uri | http://hdl.handle.net/10852/107525 | |
dc.description.abstract | Purpose
To investigate radiologists’ interpretation scores of screening mammograms prior to diagnosis of screen-detected and interval breast cancers retrospectively classified as missed or true negative.
Methods
We included data on radiologists’ interpretation scores at screening prior to diagnosis for 1223 screen-detected and 1007 interval cancer cases classified as missed or true negative in an informed consensus-based review. All prior screening examinations were independently scored 1–5 by two radiologists; score 1 by both was considered concordant negative, score ≥ 2 by one radiologist discordant, and score ≥ 2 by both concordant positive. We analyzed associations between interpretation, review categories, mammographic features and histopathological findings using descriptive statistics and logistic regression.
Results
Among screen-detected cancers, 31% of missed and 10% of true negative cancers had discordant or concordant positive interpretation at prior screening. The corresponding percentages for interval cancer were 21% and 8%. Age-adjusted odds ratio (OR) and 95% confidence interval (CI) for missed screen-detected cancer was 3.8 (95% CI: 2.6–5.4) after discordant and 5.5 (95% CI: 3.2–9.5) after concordant positive interpretation, using concordant negative as reference. Corresponding ORs for missed interval cancer were 3.0 (95% CI: 2.0–4.5) for discordant and 6.3 (95% CI: 2.3–17.5) for concordant positive interpretation. Asymmetry was the dominating mammographic feature at prior screening for all, except concordant positive screen-detected cancers where a mass dominated. Histopathological characteristics did not vary statistically with interpretation.
Conclusions
Most cancers were interpreted negatively at screening prior to diagnosis. Increased risk for missed screen-detected or interval cancer was observed after positive interpretation at prior screening. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Breast cancer missed at screening; hindsight or mistakes? | |
dc.title.alternative | ENEngelskEnglishBreast cancer missed at screening; hindsight or mistakes? | |
dc.type | Journal article | |
dc.creator.author | Hovda, Tone | |
dc.creator.author | Larsen, Marthe | |
dc.creator.author | Romundstad, Linda | |
dc.creator.author | Sahlberg, Guro Kristine Kleivi | |
dc.creator.author | Hofvind, Solveig Sand-Hanssen | |
cristin.unitcode | 185,53,49,12 | |
cristin.unitname | Institutt for kreftforskning | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2159870 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European Journal of Radiology&rft.volume=165&rft.spage=&rft.date=2023 | |
dc.identifier.jtitle | European Journal of Radiology | |
dc.identifier.volume | 165 | |
dc.identifier.pagecount | 6 | |
dc.identifier.doi | https://doi.org/10.1016/j.ejrad.2023.110913 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0720-048X | |
dc.type.version | AcceptedVersion | |
cristin.articleid | 110913 | |