European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
dc.date.accessioned | 2024-01-21T16:11:53Z | |
dc.date.available | 2024-01-21T16:11:53Z | |
dc.date.created | 2023-10-30T09:14:09Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Budu-Aggrey, Ashley Kilanowski, Anna Sobczyk, Maria K. Shringarpure, Suyash S. Mitchell, Ruth Reis, Kadri Reigo, Anu Mägi, Reedik Nelis, Mari Tanaka, Nao Brumpton, Ben Michael Thomas, Laurent Francois Sole-Navais, Pol Flatley, Christopher Espuela-Ortiz, Antonio Herrera-Luis, Esther Lominchar, Jesus V. T. Bork-Jensen, Jette Marenholz, Ingo Arnau-Soler, Aleix Jeong, Ayoung Fawcett, Katherine A. Baurecht, Hansjorg Rodriguez, Elke Alves, Alexessander Couto Kumar, Ashish Sleiman, Patrick M. Chang, Xiao Medina-Gomez, Carolina Hu, Chen Xu, Cheng-jian Qi, Cancan El-Heis, Sarah Titcombe, Philip Antoun, Elie Fadista, João Wang, Carol A. Thiering, Elisabeth Wu, Baojun Kress, Sara Kothalawala, Dilini M. Kadalayil, Latha Duan, Jiasong Zhang, Hongmei Hadebe, Sabelo Hoffmann, Thomas Jorgenson, Eric Choquet, Hélène Risch, Neil Njølstad, Pål Rasmus Andreassen, Ole Johansson, Stefan Almqvist, Catarina Gong, Tong Ullemar, Vilhelmina Karlsson, Robert Magnusson, Patrik K. E. Szwajda, Agnieszka Burchard, Esteban G. Thyssen, Jacob P. Hansen, Torben Kårhus, Line L. Dantoft, Thomas M. Jeanrenaud, Alexander C.S.N. Ghauri, Ahla Arnold, Andreas Homuth, Georg Lau, Susanne Nöthen, Markus M. Hübner, Norbert Imboden, Medea Visconti, Alessia Falchi, Mario Bataille, Veronique Hysi, Pirro Ballardini, Natalia Boomsma, Dorret I. Hottenga, Jouke J. Müller-Nurasyid, Martina Ahluwalia, Tarunveer S. Stokholm, Jakob Chawes, Bo Schoos, Ann-Marie M. Esplugues, Ana Bustamante, Mariona Raby, Benjamin Arshad, Syed German, Chris Esko, Tõnu Milani, Lili A. Metspalu, Andres Terao, Chikashi Abuabara, Katrina Løset, Mari Hveem, Kristian Jacobsson, Bo Pino-Yanes, Maria Strachan, David P. Grarup, Niels Linneberg, Allan Lee, Young-Ae Probst-Hensch, Nicole Weidinger, Stephan Jarvelin, Marjo-Riitta Melén, Erik Hakonarson, Hakon Irvine, Alan D. Jarvis, Deborah Nijsten, Tamar Duijts, Liesbeth Vonk, Judith M. Koppelmann, Gerard H. Godfrey, Keith M. Barton, Sheila J. Feenstra, Bjarke Pennell, Craig E. Sly, Peter D. Holt, Patrick G. Williams, L. Keoki Bisgaard, Hans Bønnelykke, Klaus Curtin, John Simpson, Angela Murray, Clare Schikowski, Tamara Bunyavanich, Supinda Weiss, Scott T. Holloway, John W. Min, Josine L. Brown, Sara J. Standl, Marie Paternoster, Lavinia . European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation. Nature Communications. 2023, 14(1) | |
dc.identifier.uri | http://hdl.handle.net/10852/107124 | |
dc.description.abstract | Abstract Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the populations tested (European, Latino or African), while two may be specific to individuals of Japanese ancestry. AD loci showed enrichment for DNAse I hypersensitivity and eQTL associations in blood. At each locus we prioritised candidate genes by integrating multi-omic data. The implicated genes are predominantly in immune pathways of relevance to atopic inflammation and some offer drug repurposing opportunities. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation | |
dc.title.alternative | ENEngelskEnglishEuropean and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation | |
dc.type | Journal article | |
dc.creator.author | Budu-Aggrey, Ashley | |
dc.creator.author | Kilanowski, Anna | |
dc.creator.author | Sobczyk, Maria K. | |
dc.creator.author | Shringarpure, Suyash S. | |
dc.creator.author | Mitchell, Ruth | |
dc.creator.author | Reis, Kadri | |
dc.creator.author | Reigo, Anu | |
dc.creator.author | Mägi, Reedik | |
dc.creator.author | Nelis, Mari | |
dc.creator.author | Tanaka, Nao | |
dc.creator.author | Brumpton, Ben Michael | |
dc.creator.author | Thomas, Laurent Francois | |
dc.creator.author | Sole-Navais, Pol | |
dc.creator.author | Flatley, Christopher | |
dc.creator.author | Espuela-Ortiz, Antonio | |
dc.creator.author | Herrera-Luis, Esther | |
dc.creator.author | Lominchar, Jesus V. T. | |
dc.creator.author | Bork-Jensen, Jette | |
dc.creator.author | Marenholz, Ingo | |
dc.creator.author | Arnau-Soler, Aleix | |
dc.creator.author | Jeong, Ayoung | |
dc.creator.author | Fawcett, Katherine A. | |
dc.creator.author | Baurecht, Hansjorg | |
dc.creator.author | Rodriguez, Elke | |
dc.creator.author | Alves, Alexessander Couto | |
dc.creator.author | Kumar, Ashish | |
dc.creator.author | Sleiman, Patrick M. | |
dc.creator.author | Chang, Xiao | |
dc.creator.author | Medina-Gomez, Carolina | |
dc.creator.author | Hu, Chen | |
dc.creator.author | Xu, Cheng-jian | |
dc.creator.author | Qi, Cancan | |
dc.creator.author | El-Heis, Sarah | |
dc.creator.author | Titcombe, Philip | |
dc.creator.author | Antoun, Elie | |
dc.creator.author | Fadista, João | |
dc.creator.author | Wang, Carol A. | |
dc.creator.author | Thiering, Elisabeth | |
dc.creator.author | Wu, Baojun | |
dc.creator.author | Kress, Sara | |
dc.creator.author | Kothalawala, Dilini M. | |
dc.creator.author | Kadalayil, Latha | |
dc.creator.author | Duan, Jiasong | |
dc.creator.author | Zhang, Hongmei | |
dc.creator.author | Hadebe, Sabelo | |
dc.creator.author | Hoffmann, Thomas | |
dc.creator.author | Jorgenson, Eric | |
dc.creator.author | Choquet, Hélène | |
dc.creator.author | Risch, Neil | |
dc.creator.author | Njølstad, Pål Rasmus | |
dc.creator.author | Andreassen, Ole | |
dc.creator.author | Johansson, Stefan | |
dc.creator.author | Almqvist, Catarina | |
dc.creator.author | Gong, Tong | |
dc.creator.author | Ullemar, Vilhelmina | |
dc.creator.author | Karlsson, Robert | |
dc.creator.author | Magnusson, Patrik K. E. | |
dc.creator.author | Szwajda, Agnieszka | |
dc.creator.author | Burchard, Esteban G. | |
dc.creator.author | Thyssen, Jacob P. | |
dc.creator.author | Hansen, Torben | |
dc.creator.author | Kårhus, Line L. | |
dc.creator.author | Dantoft, Thomas M. | |
dc.creator.author | Jeanrenaud, Alexander C.S.N. | |
dc.creator.author | Ghauri, Ahla | |
dc.creator.author | Arnold, Andreas | |
dc.creator.author | Homuth, Georg | |
dc.creator.author | Lau, Susanne | |
dc.creator.author | Nöthen, Markus M. | |
dc.creator.author | Hübner, Norbert | |
dc.creator.author | Imboden, Medea | |
dc.creator.author | Visconti, Alessia | |
dc.creator.author | Falchi, Mario | |
dc.creator.author | Bataille, Veronique | |
dc.creator.author | Hysi, Pirro | |
dc.creator.author | Ballardini, Natalia | |
dc.creator.author | Boomsma, Dorret I. | |
dc.creator.author | Hottenga, Jouke J. | |
dc.creator.author | Müller-Nurasyid, Martina | |
dc.creator.author | Ahluwalia, Tarunveer S. | |
dc.creator.author | Stokholm, Jakob | |
dc.creator.author | Chawes, Bo | |
dc.creator.author | Schoos, Ann-Marie M. | |
dc.creator.author | Esplugues, Ana | |
dc.creator.author | Bustamante, Mariona | |
dc.creator.author | Raby, Benjamin | |
dc.creator.author | Arshad, Syed | |
dc.creator.author | German, Chris | |
dc.creator.author | Esko, Tõnu | |
dc.creator.author | Milani, Lili A. | |
dc.creator.author | Metspalu, Andres | |
dc.creator.author | Terao, Chikashi | |
dc.creator.author | Abuabara, Katrina | |
dc.creator.author | Løset, Mari | |
dc.creator.author | Hveem, Kristian | |
dc.creator.author | Jacobsson, Bo | |
dc.creator.author | Pino-Yanes, Maria | |
dc.creator.author | Strachan, David P. | |
dc.creator.author | Grarup, Niels | |
dc.creator.author | Linneberg, Allan | |
dc.creator.author | Lee, Young-Ae | |
dc.creator.author | Probst-Hensch, Nicole | |
dc.creator.author | Weidinger, Stephan | |
dc.creator.author | Jarvelin, Marjo-Riitta | |
dc.creator.author | Melén, Erik | |
dc.creator.author | Hakonarson, Hakon | |
dc.creator.author | Irvine, Alan D. | |
dc.creator.author | Jarvis, Deborah | |
dc.creator.author | Nijsten, Tamar | |
dc.creator.author | Duijts, Liesbeth | |
dc.creator.author | Vonk, Judith M. | |
dc.creator.author | Koppelmann, Gerard H. | |
dc.creator.author | Godfrey, Keith M. | |
dc.creator.author | Barton, Sheila J. | |
dc.creator.author | Feenstra, Bjarke | |
dc.creator.author | Pennell, Craig E. | |
dc.creator.author | Sly, Peter D. | |
dc.creator.author | Holt, Patrick G. | |
dc.creator.author | Williams, L. Keoki | |
dc.creator.author | Bisgaard, Hans | |
dc.creator.author | Bønnelykke, Klaus | |
dc.creator.author | Curtin, John | |
dc.creator.author | Simpson, Angela | |
dc.creator.author | Murray, Clare | |
dc.creator.author | Schikowski, Tamara | |
dc.creator.author | Bunyavanich, Supinda | |
dc.creator.author | Weiss, Scott T. | |
dc.creator.author | Holloway, John W. | |
dc.creator.author | Min, Josine L. | |
dc.creator.author | Brown, Sara J. | |
dc.creator.author | Standl, Marie | |
dc.creator.author | Paternoster, Lavinia | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | Senter for presisjonspsykiatri | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2189756 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=14&rft.spage=&rft.date=2023 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 14 | |
dc.identifier.issue | 1 | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1038/s41467-023-41180-2 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.type.version | PublishedVersion | |
cristin.articleid | 6172 | |
dc.relation.project | NFR/315599 | |
dc.relation.project | NFR/223273 |
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