dc.date.accessioned | 2024-01-20T18:01:56Z | |
dc.date.available | 2024-01-20T18:01:56Z | |
dc.date.created | 2023-11-30T11:47:40Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Berndsen, Marta Renberg, Sara Hølmebakk, Toto Hancke, Emma Puls, Florian Karlsson, Fredrik Stoldt, Stephan Bjerkehagen, Bodil Haglund de Flon, Felix Muth, Andreas Papakonstantinou, Andri Pedersen, Kjetil Boye Lindskog, Stefan . Long-term outcome after surgical resection of non-high-risk gastrointestinal stromal tumours without adjuvant therapy. British Journal of Surgery. 2023, 110(12), 1857-1862 | |
dc.identifier.uri | http://hdl.handle.net/10852/107074 | |
dc.description.abstract | Abstract
Background
Gastrointestinal stromal tumour (GIST) is the most common intra-abdominal sarcoma. Risk classification systems, commonly the modified National Institutes of Health consensus criteria, identify tumour properties relating to patient outcomes. However, owing to limited long-term evidence, most guidelines recommend up to 10-year follow-up for all risk groups except very low-risk GIST.
Methods
This retrospective multicentre study included patients who had complete resection of primary, non-metastatic GIST from three Scandinavian sarcoma centres: Gothenburg (2004–2020), Stockholm (2000–2019), and Oslo (2000–2017). Medical records were reviewed for clinical details regarding diagnosis, treatment, and follow-up, and recurrence-free and disease-specific survival evaluated.
Results
The total cohort consisted of 1213 patients with GIST. High-risk patients and those treated with tyrosine kinase inhibitors were excluded. The remaining 649 patients were included in the present analysis: 118 with very low-, 381 with low-, and 150 with intermediate-risk GISTs. Five-year recurrence-free survival rates were 100, 98.5, and 100 per cent for the intermediate-, low-, and very low-risk groups respectively (P = 0.246). Disease-specific survival rates 10 years after surgery were 100, 98.4, and 100 per cent for the intermediate-, low-, and very low-risk groups respectively (P = 0.262).
Conclusion
Patients with completely resected non-high-risk GISTs have an excellent long-term outcome, irrespective of risk group. Follow-up programmes to detect disease recurrences in these patients are probably not indicated. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Long-term outcome after surgical resection of non-high-risk gastrointestinal stromal tumours without adjuvant therapy | |
dc.title.alternative | ENEngelskEnglishLong-term outcome after surgical resection of non-high-risk gastrointestinal stromal tumours without adjuvant therapy | |
dc.type | Journal article | |
dc.creator.author | Berndsen, Marta | |
dc.creator.author | Renberg, Sara | |
dc.creator.author | Hølmebakk, Toto | |
dc.creator.author | Hancke, Emma | |
dc.creator.author | Puls, Florian | |
dc.creator.author | Karlsson, Fredrik | |
dc.creator.author | Stoldt, Stephan | |
dc.creator.author | Bjerkehagen, Bodil | |
dc.creator.author | Haglund de Flon, Felix | |
dc.creator.author | Muth, Andreas | |
dc.creator.author | Papakonstantinou, Andri | |
dc.creator.author | Pedersen, Kjetil Boye | |
dc.creator.author | Lindskog, Stefan | |
cristin.unitcode | 185,53,18,13 | |
cristin.unitname | Avdeling for patologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2206281 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=British Journal of Surgery&rft.volume=110&rft.spage=1857&rft.date=2023 | |
dc.identifier.jtitle | British Journal of Surgery | |
dc.identifier.volume | 110 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 1857 | |
dc.identifier.endpage | 1862 | |
dc.identifier.doi | https://doi.org/10.1093/bjs/znad309 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0007-1323 | |
dc.type.version | PublishedVersion | |