dc.date.accessioned | 2024-01-19T17:48:39Z | |
dc.date.available | 2024-01-19T17:48:39Z | |
dc.date.created | 2023-07-04T15:55:06Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Lluís, Núria Serradilla-Martín, Mario Achalandabaso, Mar Jehaes, François Dasari, Bobby V M Mambrilla-Herrero, Sara Sparrelid, Ernesto Balakrishnan, Anita Hoogwater, Frederik J H Amaral, Maria J. Andersson, Bodil Berrevoet, Frederik Doussot, Alexandre López-López, Víctor Alsammani, Mohammedsuror Detry, Olivier Domingo-Del Pozo, Carlos Machairas, Nikolaos Pekli, Damján Alcázar-López, Cándido F Asbun, Horacio Björnsson, Bergthor Christophides, Thalis Díez-Caballero, Alberto Francart, David Noel, Colin B. Sousa-Silva, Donzília Toledo-Martínez, Enrique Tzimas, George N. Yakub, Sheraz Cauchy, François Prieto-Calvo, Mikel D'Souza, Melroy A. Spiers, Harry V M van den Heuvel, Marius C. Charco, Ramón Lesurtel, Mickaël Ramia, José M . Intraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study). International Journal of Surgery (IJS). 2023, 109(4), 760-771 | |
dc.identifier.uri | http://hdl.handle.net/10852/107034 | |
dc.description.abstract | Background/Purpose:
Intraductal papillary neoplasm of the bile duct (IPNB) is a rare disease in Western countries. The main aim of this study was to characterize current surgical strategies and outcomes in the mainly European participating centers.
Methods:
A multi-institutional retrospective series of patients with a diagnosis of IPNB undergoing surgery between 1 January 2010 and 31 December 2020 was gathered under the auspices of the European-African Hepato-Pancreato-Biliary Association. The textbook outcome (TO) was defined as a non-prolonged length of hospital stay plus the absence of any Clavien–Dindo grade at least III complications, readmission, or mortality within 90 postoperative days.
Results:
A total of 28 centers contributed 85 patients who underwent surgery for IPNB. The median age was 66 years (55–72), 49.4% were women, and 87.1% were Caucasian. Open surgery was performed in 72 patients (84.7%) and laparoscopic in 13 (15.3%). TO was achieved in 54.1% of patients, reaching 63.8% after liver resection and 32.0% after pancreas resection. Median overall survival was 5.72 years, with 5-year overall survival of 63% (95% CI: 50–82). Overall survival was better in patients with Charlson comorbidity score 4 or less versus more than 4 (P=0.016), intrahepatic versus extrahepatic tumor (P=0.027), single versus multiple tumors (P=0.007), those who underwent hepatic versus pancreatic resection (P=0.017), or achieved versus failed TO (P=0.029). Multivariable Cox regression analysis showed that not achieving TO (HR: 4.20; 95% CI: 1.11–15.94; P=0.03) was an independent prognostic factor of poor overall survival.
Conclusions:
Patients undergoing liver resection for IPNB were more likely to achieve a TO outcome than those requiring a pancreatic resection. Comorbidity, tumor location, and tumor multiplicity influenced overall survival. TO was an independent prognostic factor of overall survival. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Intraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study) | |
dc.title.alternative | ENEngelskEnglishIntraductal papillary neoplasms of the bile duct: a European retrospective multicenter observational study (EUR-IPNB study) | |
dc.type | Journal article | |
dc.creator.author | Lluís, Núria | |
dc.creator.author | Serradilla-Martín, Mario | |
dc.creator.author | Achalandabaso, Mar | |
dc.creator.author | Jehaes, François | |
dc.creator.author | Dasari, Bobby V M | |
dc.creator.author | Mambrilla-Herrero, Sara | |
dc.creator.author | Sparrelid, Ernesto | |
dc.creator.author | Balakrishnan, Anita | |
dc.creator.author | Hoogwater, Frederik J H | |
dc.creator.author | Amaral, Maria J. | |
dc.creator.author | Andersson, Bodil | |
dc.creator.author | Berrevoet, Frederik | |
dc.creator.author | Doussot, Alexandre | |
dc.creator.author | López-López, Víctor | |
dc.creator.author | Alsammani, Mohammedsuror | |
dc.creator.author | Detry, Olivier | |
dc.creator.author | Domingo-Del Pozo, Carlos | |
dc.creator.author | Machairas, Nikolaos | |
dc.creator.author | Pekli, Damján | |
dc.creator.author | Alcázar-López, Cándido F | |
dc.creator.author | Asbun, Horacio | |
dc.creator.author | Björnsson, Bergthor | |
dc.creator.author | Christophides, Thalis | |
dc.creator.author | Díez-Caballero, Alberto | |
dc.creator.author | Francart, David | |
dc.creator.author | Noel, Colin B. | |
dc.creator.author | Sousa-Silva, Donzília | |
dc.creator.author | Toledo-Martínez, Enrique | |
dc.creator.author | Tzimas, George N. | |
dc.creator.author | Yakub, Sheraz | |
dc.creator.author | Cauchy, François | |
dc.creator.author | Prieto-Calvo, Mikel | |
dc.creator.author | D'Souza, Melroy A. | |
dc.creator.author | Spiers, Harry V M | |
dc.creator.author | van den Heuvel, Marius C. | |
dc.creator.author | Charco, Ramón | |
dc.creator.author | Lesurtel, Mickaël | |
dc.creator.author | Ramia, José M | |
cristin.unitcode | 185,53,48,10 | |
cristin.unitname | Avdeling for gastro- og barnekirurgi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2160813 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International Journal of Surgery (IJS)&rft.volume=109&rft.spage=760&rft.date=2023 | |
dc.identifier.jtitle | International Journal of Surgery (IJS) | |
dc.identifier.volume | 109 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 760 | |
dc.identifier.endpage | 771 | |
dc.identifier.doi | https://doi.org/10.1097/JS9.0000000000000280 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1743-9191 | |
dc.type.version | PublishedVersion | |