dc.date.accessioned | 2024-01-17T17:39:35Z | |
dc.date.available | 2024-01-17T17:39:35Z | |
dc.date.created | 2023-02-09T15:09:59Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Nafisi, Sara Randel, Kristin Ranheim Støer, Nathalie C. Veierød, Marit B. Hoff, Geir Svein Holme, Øyvind Schult, Anna L. Botteri, Edoardo . Association between use of low-dose aspirin and detection of colorectal polyps and cancer in a screening setting. Digestive and Liver Disease. 2023, 55, 1126-1132 | |
dc.identifier.uri | http://hdl.handle.net/10852/106929 | |
dc.description.abstract | Background: The possible protective effect of aspirin on risk of colorectal cancer (CRC) is still highly debated. Methods: We used data from Bowel Cancer Screening in Norway, a trial randomizing individuals from general population, aged 50-74 years, to flexible sigmoidoscopy or faecal immunochemical test (FIT), to study the association between aspirin use and detection of CRC and two CRC precursors: adenomas and advanced serrated lesions (ASL). Prescriptions of low-dose aspirin were obtained from Norwegian prescription database. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: Among 64,889 screening participants (24,159 sigmoidoscopy, 40,730 FIT), 314 (0.5%) had CRC, 6,208 (9.6%) adenoma and 659 (1.0%) ASL. Overall and short-term use (<3 years) of low-dose aspirin, versus no use, were not associated with any colorectal lesion. Long-term use (≥3 years) was associated with lower detection of CRC (overall OR 0.66, 95%CI 0.46-0.93; sigmoidoscopy: 0.56, 0.33-0.97; FIT: 0.72, 0.45-1.15), adenomas in sigmoidoscopy arm (overall OR 0.95, 95%CI 0.87-1.03; sigmoidoscopy: 0.89, 0.80-0.99; FIT: 1.03, 0.89-1.18), but not ASLs. We did not observe significant differences in the effect of aspirin according to the location of colorectal lesions. Conclusion: Our results suggest that long-term use of aspirin might have a protective effect against adenomas and colorectal cancer, but not ASLs. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Association between use of low-dose aspirin and detection of colorectal polyps and cancer in a screening setting | |
dc.title.alternative | ENEngelskEnglishAssociation between use of low-dose aspirin and detection of colorectal polyps and cancer in a screening setting | |
dc.type | Journal article | |
dc.creator.author | Nafisi, Sara | |
dc.creator.author | Randel, Kristin Ranheim | |
dc.creator.author | Støer, Nathalie C. | |
dc.creator.author | Veierød, Marit B. | |
dc.creator.author | Hoff, Geir Svein | |
dc.creator.author | Holme, Øyvind | |
dc.creator.author | Schult, Anna L. | |
dc.creator.author | Botteri, Edoardo | |
cristin.unitcode | 185,53,48,0 | |
cristin.unitname | Klinikk for kirurgi, inflammasjonsmedisin og transplantasjon | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2124628 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Digestive and Liver Disease&rft.volume=55&rft.spage=1126&rft.date=2023 | |
dc.identifier.jtitle | Digestive and Liver Disease | |
dc.identifier.volume | 55 | |
dc.identifier.issue | 8 | |
dc.identifier.startpage | 1126 | |
dc.identifier.endpage | 1132 | |
dc.identifier.doi | https://doi.org/10.1016/j.dld.2023.01.156 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1590-8658 | |
dc.type.version | PublishedVersion | |