dc.date.accessioned | 2024-01-16T16:23:06Z | |
dc.date.available | 2024-01-16T16:23:06Z | |
dc.date.created | 2023-02-27T13:35:36Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Chlubnova, Marketa Christophersen, Asbjørn Otto Sandve, Geir Kjetil Ferkingstad Lundin, Knut Erik Aslaksen Jahnsen, Jørgen Dahal-Koirala, Shiva Sollid, Ludvig Magne . Identification of gluten T cell epitopes driving celiac disease. Science Advances. 2023, 9(4), 1-8 | |
dc.identifier.uri | http://hdl.handle.net/10852/106890 | |
dc.description.abstract | CD4+ T cells specific for cereal gluten proteins are key players in celiac disease (CeD) pathogenesis. While several CeD-relevant gluten T cell epitopes have been identified, epitopes recognized by a substantial proportion of gluten-reactive T cells remain unknown. The identification of such CeD-driving gluten epitopes is important for the food industry and in clinical settings. Here, we have combined the knowledge of a distinct phenotype of gluten-reactive T cells and key features of known gluten epitopes for the discovery of unknown epitopes. We tested 42 wheat gluten–reactive T cell clones, isolated on the basis of their distinct phenotype and with no reactivity to known epitopes, against a panel of synthetic peptides bioinformatically identified from a wheat gluten protein database. We were able to assign reactivity to 10 T cell clones and identified a 9-nucleotide oligomer core region of five previously uncharacterized gliadin/glutenin epitopes. This work represents an advance in the effort to identify CeD-driving gluten epitopes. | |
dc.language | EN | |
dc.publisher | American Association for the Advancement of Science | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Identification of gluten T cell epitopes driving celiac disease | |
dc.title.alternative | ENEngelskEnglishIdentification of gluten T cell epitopes driving celiac disease | |
dc.type | Journal article | |
dc.creator.author | Chlubnova, Marketa | |
dc.creator.author | Christophersen, Asbjørn Otto | |
dc.creator.author | Sandve, Geir Kjetil Ferkingstad | |
dc.creator.author | Lundin, Knut Erik Aslaksen | |
dc.creator.author | Jahnsen, Jørgen | |
dc.creator.author | Dahal-Koirala, Shiva | |
dc.creator.author | Sollid, Ludvig Magne | |
cristin.unitcode | 185,53,18,12 | |
cristin.unitname | Avdeling for immunologi og transfusjonsmedisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2129651 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science Advances&rft.volume=9&rft.spage=1&rft.date=2023 | |
dc.identifier.jtitle | Science Advances | |
dc.identifier.volume | 9 | |
dc.identifier.issue | 4 | |
dc.identifier.doi | https://doi.org/10.1126/sciadv.ade5800 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2375-2548 | |
dc.type.version | PublishedVersion | |
cristin.articleid | eade5800 | |
dc.relation.project | NFR/187615 | |
dc.relation.project | SKGJ/SKGJ-MED-017 | |