dc.date.accessioned | 2024-01-15T18:14:16Z | |
dc.date.available | 2024-01-15T18:14:16Z | |
dc.date.created | 2023-10-23T11:02:50Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Kared, Hassen Alirezaylavasani, Amin Lund, Katrine Persgård Chopra, Adity Tietze, Lisa de Matos Kasahara, Taissa Goll, Guro Løvik Grødeland, Gunnveig Kaarbø, Mari Reisæter, Anna Varberg Hovd, Markus Herberg Vaage, John T. Lund-Johansen, Fridtjof Midtvedt, Karsten Åsberg, Anders Munthe, Ludvig Andre . Hybrid and SARS-CoV-2-vaccine immunity in kidney transplant recipients. EBioMedicine. 2023, 97 | |
dc.identifier.uri | http://hdl.handle.net/10852/106837 | |
dc.description.abstract | Background
Kidney transplant recipients (KTR) are at high risk for severe COVID-19 and have demonstrated poor response to vaccination, making it unclear whether successive vaccinations offer immunity and protection.
Methods
We conducted a serologically guided interventional study where KTR patients that failed to seroconvert were revaccinated and also monitored seroconversion of KTR following the Norwegian vaccination program. We analysed IgG anti-RBD Spike responses from dose 2 (n = 432) up to after the 6th (n = 37) mRNA vaccine dose. The frequency and phenotype of Spike-specific T and B cell responses were assessed in the interventional cohort after 3–4 vaccine doses (n = 30). Additionally, we evaluated the Specific T and B cell response to breakthrough infection (n = 32), measured inflammatory cytokines and broadly cross-neutralizing antibodies, and defined the incidence of COVID-19-related hospitalizations and deaths. The Norwegian KTR cohort has a male dominance (2323 males, 1297 females), PBMC were collected from 114 male and 78 female donors.
Findings
After vaccine dose 3, most KTR developed Spike-specific T cell responses but had significantly reduced Spike-binding B cells and few memory cells. The B cell response included a cross-reactive subset that could bind Omicron VOC, which expanded after breakthrough infection (BTI) and gave rise to a memory IgG+ B cell response. After BTI, KTR had increased Spike-specific T cells, emergent non-Spike T and B cell responses, and a systemic inflammatory signature. Late seroconversion occurred after doses 5–6, but 38% (14/37) of KTR had no detectable immunity even after multiple vaccine doses.
Interpretation
Boosting vaccination can induce Spike-specific immunity that may expand in breakthrough infections highlighting the benefit of vaccination to protect this vulnerable population. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Hybrid and SARS-CoV-2-vaccine immunity in kidney transplant recipients | |
dc.title.alternative | ENEngelskEnglishHybrid and SARS-CoV-2-vaccine immunity in kidney transplant recipients | |
dc.type | Journal article | |
dc.creator.author | Kared, Hassen | |
dc.creator.author | Alirezaylavasani, Amin | |
dc.creator.author | Lund, Katrine Persgård | |
dc.creator.author | Chopra, Adity | |
dc.creator.author | Tietze, Lisa | |
dc.creator.author | de Matos Kasahara, Taissa | |
dc.creator.author | Goll, Guro Løvik | |
dc.creator.author | Grødeland, Gunnveig | |
dc.creator.author | Kaarbø, Mari | |
dc.creator.author | Reisæter, Anna Varberg | |
dc.creator.author | Hovd, Markus Herberg | |
dc.creator.author | Vaage, John T. | |
dc.creator.author | Lund-Johansen, Fridtjof | |
dc.creator.author | Midtvedt, Karsten | |
dc.creator.author | Åsberg, Anders | |
dc.creator.author | Munthe, Ludvig Andre | |
cristin.unitcode | 185,53,18,12 | |
cristin.unitname | Avdeling for immunologi og transfusjonsmedisin | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2187542 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=EBioMedicine&rft.volume=97&rft.spage=&rft.date=2023 | |
dc.identifier.jtitle | EBioMedicine | |
dc.identifier.volume | 97 | |
dc.identifier.pagecount | 18 | |
dc.identifier.doi | https://doi.org/10.1016/j.ebiom.2023.104833 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2352-3964 | |
dc.type.version | PublishedVersion | |
cristin.articleid | 104833 | |
dc.relation.project | NFR/328657 | |