dc.date.accessioned | 2023-12-19T16:48:04Z | |
dc.date.available | 2023-12-19T16:48:04Z | |
dc.date.created | 2023-12-18T10:28:26Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Schellhas, Laura Monasso, Giulietta S. Felix, Janine F. Jaddoe, Vincent WV Huang, Peiyuan Fernández-Barrés, Sílvia Vrijheid, Martine Pesce, Giancarlo Annesi-Maesano, Isabella Page, Christian Magnus Brantsæter, Anne Lise Bekkhus, Mona Håberg, Siri Eldevik London, Stephanie J. Munafò, Marcus R. Zuccolo, Luisa Sharp, Gemma C. . Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis. Epigenomics. 2023 | |
dc.identifier.uri | http://hdl.handle.net/10852/106502 | |
dc.description.abstract | Background: Prenatal caffeine exposure may influence offspring health via DNA methylation, but no large studies have tested this. Materials & methods: Epigenome-wide association studies and differentially methylated regions in cord blood (450k or EPIC Illumina arrays) were meta-analyzed across six European cohorts (n = 3725). Differential methylation related to self-reported caffeine intake (mg/day) from coffee, tea and cola was compared with assess whether caffeine is driving effects. Results: One CpG site (cg19370043, PRRX1) was associated with caffeine and another (cg14591243, STAG1) with cola intake. A total of 12–22 differentially methylated regions were detected with limited overlap across caffeinated beverages. Conclusion: We found little evidence to support an intrauterine effect of caffeine on offspring DNA methylation. Statistical power limitations may have impacted our findings. | |
dc.language | EN | |
dc.publisher | Future Medicine Ltd. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis | |
dc.title.alternative | ENEngelskEnglishMaternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis | |
dc.type | Journal article | |
dc.creator.author | Schellhas, Laura | |
dc.creator.author | Monasso, Giulietta S. | |
dc.creator.author | Felix, Janine F. | |
dc.creator.author | Jaddoe, Vincent WV | |
dc.creator.author | Huang, Peiyuan | |
dc.creator.author | Fernández-Barrés, Sílvia | |
dc.creator.author | Vrijheid, Martine | |
dc.creator.author | Pesce, Giancarlo | |
dc.creator.author | Annesi-Maesano, Isabella | |
dc.creator.author | Page, Christian Magnus | |
dc.creator.author | Brantsæter, Anne Lise | |
dc.creator.author | Bekkhus, Mona | |
dc.creator.author | Håberg, Siri Eldevik | |
dc.creator.author | London, Stephanie J. | |
dc.creator.author | Munafò, Marcus R. | |
dc.creator.author | Zuccolo, Luisa | |
dc.creator.author | Sharp, Gemma C. | |
cristin.unitcode | 185,17,5,7 | |
cristin.unitname | Helse-, utviklings- og personlighetspsyk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2214708 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Epigenomics&rft.volume=&rft.spage=&rft.date=2023 | |
dc.identifier.jtitle | Epigenomics | |
dc.identifier.volume | 15 | |
dc.identifier.issue | 22 | |
dc.identifier.doi | https://doi.org/10.2217/epi-2023-0263 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1750-1911 | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/221097 | |
dc.relation.project | NFR/262700 | |
dc.relation.project | ERC/268479-BREATHE | |