dc.date.accessioned | 2023-12-19T09:23:44Z | |
dc.date.available | 2023-12-19T09:23:44Z | |
dc.date.issued | 2023 | |
dc.identifier.isbn | 978-82-348-0310-9 | |
dc.identifier.uri | http://hdl.handle.net/10852/106455 | |
dc.description.abstract | In Norway, a tenfold increase in narcolepsy type 1 (NT1) was observed after the 2009 influenza A (H1N1) pandemic and Pandemrix-vaccination campaign. It is still discussed whether NT1 with debut after the H1N1-pandemic is the same disease as pre-H1N1 NT1. However, based on a similar immunogenetic predisposition (HLA and some non-HLA genes), most evidence point towards it being the same entity. In this thesis, we aimed to improve the understanding of post-H1N1 NT1 pathogenesis.
The cohort comprised HLA-DQB1*06:02 positive NT1 patients, mostly vaccinated, solely with onset post-H1N1, and their first-degree relatives. Relationship between the genotyped NT1 risk polymorphism rs2305795 in the P2RY11 gene, core narcolepsy symptoms and sleep features, and T cell levels of the gene product receptor P2Y11 (assessed with flow cytometry) were investigated. Flow cytometry was also used to investigate T cell differentiation and levels of two activation markers. Sleep studies and self-report questionnaires were utilized to investigate nighttime muscle activity, and finally we reported on immunomodulation therapy administered in two case reports.
We found a negative correlation between high nocturnal sleep fragmentation, a cardinal symptom of NT1, and low T cell levels of the receptor P2Y11. This suggests that the P2Y11 receptor can have a role in central regulation of sleep stability in NT1 patients. T cell differentiation is not specific for NT1 and cannot be used as disease marker. Muscle activity and RBD in sleep are also significantly increased in post-H1N1 NT1. Decreased sleepiness is observed in one case 18 months after treatment with combined immune modulation therapy administered close to disease onset, which suggests that some NT1 patients can have beneficial effect from immunomodulating treatment.
Overall, the findings point towards shared NT1 pathogenesis in pre-H1N1 and post-H1N1 NT1. We did not find strong evidence for disease continuum in first-degree relatives. | en_US |
dc.language.iso | en | en_US |
dc.relation.haspart | Paper I: Viste, R., Viken, M.K., Lie, B. A., Juvodden H. T., Nordstrand, S. E. H., Thorsby, P. M., Rootwelt, T., Kornum, B. R., and Knudsen-Heier, S. (2021) High nocturnal sleep fragmentation is associated with low T lymphocyte P2Y11 protein levels in narcolepsy type 1. Sleep, Vol. 44, Issue 8. Doi: 10.1093/sleep/zsab062. The article is included in the thesis. Also available at: https://doi.org/10.1093/sleep/zsab062 | |
dc.relation.haspart | Paper II: Viste, R., Lie, B. A., Viken, M. K., Rootwelt, T., Knudsen-Heier, S., and Kornum, B. R. (2021) Narcolepsy type 1 patients have lower levels of effector memory CD4+ T cells compared to their siblings when controlling for H1N1-(Pandemrix)-vaccination and HLA DQB1*06:02 status. Sleep Medicine, Vol. 85, Pages 271-279. Doi: 10.1016/j.sleep.2021.07.024. The article is included in the thesis. Also available at: https://doi.org/10.1016/j.sleep.2021.07.024 | |
dc.relation.haspart | Paper III: Viste, R., Follin, L. F., Kornum, B. R., Lie, B. A., Viken, M. K., Thorsby, P. M., Rootwelt, T., Christensen, J. A. E., and Knudsen-Heier, S. (2023). Increased muscle activity during sleep and more RBD symptoms in H1N1-(Pandemrix)-vaccinated narcolepsy type 1 patients compared with their non-narcoleptic siblings. Sleep, Vol. 46, Issue 3. Doi: 10.1093/sleep/zsac316. The article is included in the thesis. Also available at: https://doi.org/10.1093/sleep/zsac316 | |
dc.relation.haspart | Paper IV: Viste, R., Soosai, J., Vikin, T., Thorsby, P. M., Nilsen K. B., and Knudsen, S. (2017) Long-term improvement after combined immunomodulation in early post-H1N1 vaccination narcolepsy. Neurology: Neuroimmunology & Neuroinflammation, 4 (5), e389. Doi: 10.1212/NXI.0000000000000389. The article is included in the thesis. Also available at: https://doi.org/10.1212/NXI.0000000000000389 | |
dc.relation.uri | https://doi.org/10.1093/sleep/zsab062v | |
dc.relation.uri | https://doi.org/10.1016/j.sleep.2021.07.024 | |
dc.relation.uri | https://doi.org/10.1093/sleep/zsac316 | |
dc.relation.uri | https://doi.org/10.1212/NXI.0000000000000389 | |
dc.title | Narcolepsy after the H1N1 pandemic - an immunogenetic approach for understanding post-H1N1 narcolepsy type 1 pathogenesis | en_US |
dc.type | Doctoral thesis | en_US |
dc.creator.author | Viste, Rannveig | |
dc.type.document | Doktoravhandling | en_US |