dc.date.accessioned | 2023-12-14T16:48:55Z | |
dc.date.available | 2023-12-14T16:48:55Z | |
dc.date.created | 2023-12-08T10:22:42Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Nilsen, Morten Nygaard, Unni Cecilie Brodin, Petter Carlsen, Karin Cecilie Lødrup Fredheim, Cecilie Haugen, Guttorm Nils Hedlin, Gunilla Monceyron Jonassen, Christine Jonsmoen, Unni Lise Albertsdottir Lakshmikanth, Tadepally Nordlund, Björn Olin, Axel Rehbinder, Eva Maria Skjerven, Håvard O. Snipen, Lars Staff, Anne Cathrine Söderhäll, Cilla Vettukattil, Muhammad Riyas Rudi, Knut . Gut bacteria at 6 months of age are associated with immune cell status in 1-year-old children. Immunology. 2023, 1-12 | |
dc.identifier.uri | http://hdl.handle.net/10852/106384 | |
dc.description.abstract | Age-related gut bacterial changes during infancy have been widely studied, but it remains still unknown how these changes are associated with immune cell composition. This study's aim was to explore if the temporal development of gut bacteria during infancy prospectively affects immune cell composition. Faecal bacteria and short-chain fatty acids were analysed from 67 PreventADALL study participants at four timepoints (birth to 12 months) using reduced metagenome sequencing and gas chromatography. Immune cell frequencies were assessed using mass cytometry in whole blood samples at 12 months. The infants clustered into four groups based on immune cell composition: clusters 1 and 2 showed a high relative abundance of naïve cells, cluster 3 exhibited increased abundance of classical- and non-classical monocytes and clusters 3 and 4 had elevated neutrophil levels. At all age groups, we did observe significant associations between the gut microbiota and immune cell clusters; however, these were generally from low abundant species. Only at 6 months of age we observed significant associations between abundant (>8%) species and immune cell clusters. Bifidobacterium adolescentis and Porphyromonadaceae are associated with cluster 1, while Bacteroides fragilis and Bifidobacterium longum are associated with clusters 3 and 4 respectively. These species have been linked to T-cell polarization and maturation. No significant correlations were found between short-chain fatty acids and immune cell composition. Our findings suggest that abundant gut bacteria at 6 months may influence immune cell frequencies at 12 months, highlighting the potential role of gut microbiota in shaping later immune cell composition. | |
dc.language | EN | |
dc.publisher | Blackwell Science Ltd. | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Gut bacteria at 6 months of age are associated with immune cell status in 1-year-old children | |
dc.title.alternative | ENEngelskEnglishGut bacteria at 6 months of age are associated with immune cell status in 1-year-old children | |
dc.type | Journal article | |
dc.creator.author | Nilsen, Morten | |
dc.creator.author | Nygaard, Unni Cecilie | |
dc.creator.author | Brodin, Petter | |
dc.creator.author | Carlsen, Karin Cecilie Lødrup | |
dc.creator.author | Fredheim, Cecilie | |
dc.creator.author | Haugen, Guttorm Nils | |
dc.creator.author | Hedlin, Gunilla | |
dc.creator.author | Monceyron Jonassen, Christine | |
dc.creator.author | Jonsmoen, Unni Lise Albertsdottir | |
dc.creator.author | Lakshmikanth, Tadepally | |
dc.creator.author | Nordlund, Björn | |
dc.creator.author | Olin, Axel | |
dc.creator.author | Rehbinder, Eva Maria | |
dc.creator.author | Skjerven, Håvard O. | |
dc.creator.author | Snipen, Lars | |
dc.creator.author | Staff, Anne Cathrine | |
dc.creator.author | Söderhäll, Cilla | |
dc.creator.author | Vettukattil, Muhammad Riyas | |
dc.creator.author | Rudi, Knut | |
cristin.unitcode | 185,53,46,10 | |
cristin.unitname | Pediatri | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2210851 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Immunology&rft.volume=&rft.spage=1&rft.date=2023 | |
dc.identifier.jtitle | Immunology | |
dc.identifier.doi | https://doi.org/10.1111/sji.13346 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0019-2805 | |
dc.type.version | PublishedVersion | |
cristin.articleid | e13346 | |