Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock
dc.date.accessioned | 2023-12-12T09:03:45Z | |
dc.date.available | 2023-12-12T09:03:45Z | |
dc.date.created | 2023-07-04T13:21:11Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Kjær, Maj-Brit Nørregaard Meyhoff, Tine Sylvest Sivapalan, Praleene Granholm, Anders Hjortrup, Peter Buhl Madsen, Martin Bruun Møller, Morten Hylander Egerod, Ingrid Wetterslev, Jørn Lange, Theis Cronhjort, Maria Laake, Jon Henrik Jakob, Stephan M. Nalos, Marek Ostermann, Marlies Gould, Doug Cecconi, Maurizio Malbrain, Manu L. N. G. Ahlstedt, Christian Kiel, Louise Bendix Bestle, Morten H. Nebrich, Lars Hildebrandt, Thomas Russell, Lene Vang, Marianne Rasmussen, Michael Lindhart Sølling, Christoffer Brøchner, Anne Craveiro Krag, Mette Pfortmueller, Carmen Kriz, Miroslav Siegemund, Martin Albano, Giovanni Aagaard, Søren Rosborg Bundgaard, Helle Crone, Vera Wichmann, Sine Johnstad, Bror Anders Martin, Yvonne Karin Seidel, Philipp Mårtensson, Johan Hollenberg, Jacob Wistrand, Mats Donati, Abele Barbara, Enrico Karvunidis, Thomas Hollinger, Alexa Carsetti, Andrea Lumlertgul, Nuttha Joelsson-Alm, Eva Lambiris, Nikolas Aslam, Tayyba Naz Friberg, Fredrik Femtehjell Vesterlund, Gitte Kingo Mortensen, Camilla Bekker Vestergaard, Stine Rom Caspersen, Sidsel Fjordbak Jensen, Diana Bertelsen Borup, Morten Rasmussen, Bodil Steen Perner, Anders . Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock. Intensive Care Medicine. 2023, 49(7), 820-830 | |
dc.identifier.uri | http://hdl.handle.net/10852/106267 | |
dc.description.abstract | Purpose: To assess long-term outcomes of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock included in the European Conservative versus Liberal Approach to Fluid Therapy in Septic Shock in Intensive Care (CLASSIC) trial. Methods: We conducted the pre-planned analyses of mortality, health-related quality of life (HRQoL) using EuroQol (EQ)-5D-5L index values and EQ visual analogue scale (VAS), and cognitive function using Mini Montreal Cognitive Assessment (Mini MoCA) test at 1 year. Deceased patients were assigned numerical zero for HRQoL as a state equal to death and zero for cognitive function outcomes as worst possible score, and we used multiple imputation for missing data on HRQoL and cognitive function. Results: Among 1554 randomized patients, we obtained 1-year data on mortality in 97.9% of patients, HRQoL in 91.3%, and cognitive function in 86.3%. One-year mortality was 385/746 (51.3%) in the restrictive-fluid group versus 383/767 (49.9%) in the standard-fluid group, absolute risk difference 1.5%-points [99% confidence interval (CI) - 4.8 to 7.8]. Mean differences were 0.00 (99% CI - 0.06 to 0.05) for EQ-5D-5L index values, - 0.65 for EQ VAS (- 5.40 to 4.08), and - 0.14 for Mini MoCA (- 1.59 to 1.14) for the restrictive-fluid group versus the standard-fluid group. The results for survivors only were similar in both groups. Conclusions: Among adult ICU patients with septic shock, restrictive versus standard IV fluid therapy resulted in similar survival, HRQoL, and cognitive function at 1 year, but clinically important differences could not be ruled out. Trial registration: ClinicalTrials.gov NCT03668236. Keywords: Cognitive function; Critical illness; Intravenous fluid; Long-term outcomes; Quality of life; Sepsis; Septic shock. © 2023. The Author(s). | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Long-term effects of restriction of intravenous fluid in adult ICU patients with septic shock | |
dc.title.alternative | ENEngelskEnglishLong-term effects of restriction of intravenous fluid in adult ICU patients with septic shock | |
dc.type | Journal article | |
dc.creator.author | Kjær, Maj-Brit Nørregaard | |
dc.creator.author | Meyhoff, Tine Sylvest | |
dc.creator.author | Sivapalan, Praleene | |
dc.creator.author | Granholm, Anders | |
dc.creator.author | Hjortrup, Peter Buhl | |
dc.creator.author | Madsen, Martin Bruun | |
dc.creator.author | Møller, Morten Hylander | |
dc.creator.author | Egerod, Ingrid | |
dc.creator.author | Wetterslev, Jørn | |
dc.creator.author | Lange, Theis | |
dc.creator.author | Cronhjort, Maria | |
dc.creator.author | Laake, Jon Henrik | |
dc.creator.author | Jakob, Stephan M. | |
dc.creator.author | Nalos, Marek | |
dc.creator.author | Ostermann, Marlies | |
dc.creator.author | Gould, Doug | |
dc.creator.author | Cecconi, Maurizio | |
dc.creator.author | Malbrain, Manu L. N. G. | |
dc.creator.author | Ahlstedt, Christian | |
dc.creator.author | Kiel, Louise Bendix | |
dc.creator.author | Bestle, Morten H. | |
dc.creator.author | Nebrich, Lars | |
dc.creator.author | Hildebrandt, Thomas | |
dc.creator.author | Russell, Lene | |
dc.creator.author | Vang, Marianne | |
dc.creator.author | Rasmussen, Michael Lindhart | |
dc.creator.author | Sølling, Christoffer | |
dc.creator.author | Brøchner, Anne Craveiro | |
dc.creator.author | Krag, Mette | |
dc.creator.author | Pfortmueller, Carmen | |
dc.creator.author | Kriz, Miroslav | |
dc.creator.author | Siegemund, Martin | |
dc.creator.author | Albano, Giovanni | |
dc.creator.author | Aagaard, Søren Rosborg | |
dc.creator.author | Bundgaard, Helle | |
dc.creator.author | Crone, Vera | |
dc.creator.author | Wichmann, Sine | |
dc.creator.author | Johnstad, Bror Anders | |
dc.creator.author | Martin, Yvonne Karin | |
dc.creator.author | Seidel, Philipp | |
dc.creator.author | Mårtensson, Johan | |
dc.creator.author | Hollenberg, Jacob | |
dc.creator.author | Wistrand, Mats | |
dc.creator.author | Donati, Abele | |
dc.creator.author | Barbara, Enrico | |
dc.creator.author | Karvunidis, Thomas | |
dc.creator.author | Hollinger, Alexa | |
dc.creator.author | Carsetti, Andrea | |
dc.creator.author | Lumlertgul, Nuttha | |
dc.creator.author | Joelsson-Alm, Eva | |
dc.creator.author | Lambiris, Nikolas | |
dc.creator.author | Aslam, Tayyba Naz | |
dc.creator.author | Friberg, Fredrik Femtehjell | |
dc.creator.author | Vesterlund, Gitte Kingo | |
dc.creator.author | Mortensen, Camilla Bekker | |
dc.creator.author | Vestergaard, Stine Rom | |
dc.creator.author | Caspersen, Sidsel Fjordbak | |
dc.creator.author | Jensen, Diana Bertelsen | |
dc.creator.author | Borup, Morten | |
dc.creator.author | Rasmussen, Bodil Steen | |
dc.creator.author | Perner, Anders | |
cristin.unitcode | 185,0,0,0 | |
cristin.unitname | Universitetet i Oslo | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2160667 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Intensive Care Medicine&rft.volume=49&rft.spage=820&rft.date=2023 | |
dc.identifier.jtitle | Intensive Care Medicine | |
dc.identifier.volume | 49 | |
dc.identifier.issue | 7 | |
dc.identifier.startpage | 820 | |
dc.identifier.endpage | 830 | |
dc.identifier.doi | https://doi.org/10.1007/s00134-023-07114-8 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0342-4642 | |
dc.type.version | PublishedVersion |
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