| dc.date.accessioned | 2023-12-06T07:32:55Z | |
| dc.date.available | 2023-12-06T07:32:55Z | |
| dc.date.issued | 2023 | |
| dc.identifier.isbn | 978-82-348-0299-7 | |
| dc.identifier.uri | http://hdl.handle.net/10852/106182 | |
| dc.description.abstract | Despite urgent myocardial reperfusion with percutaneous coronary intervention (PCI), morbidity and mortality remain substantial in patients presenting with acute myocardial infarction. Adjuvant therapeutic strategies targeting inflammation might limit infarct size and improve outcomes.
The overall aim of this thesis was to assess the effect of anti-inflammatory strategy of Interleukin-6 (IL-6) inhibition as an adjuvant therapy to improve myocardial salvage and limit irreversible myocardial injury in patients with acute ST-elevation myocardial infarction (STEMI).
This investigator-initiated phase 2, randomized-controlled trial of 199 first-time STEMI patients was conducted at three high-volume PCI-centers in Norway. Our results show that IL-6 receptor inhibition improves myocardial salvage in STEMI patients presenting within 6 hours from symptom onset of PCI.
IL-6 receptor inhibition in acute myocardial infarction is a promising anti-inflammatory target to limit infarct size and might be further investigated in larger endpoint-driven clinical trials. | en_US |
| dc.language.iso | en | en_US |
| dc.relation.haspart | Paper I: Anstensrud AK, Woxholt S, Sharma K, Broch K, Bendz B, Aakhus S, Ueland T, Amundsen B, Damås JK, Hopp E, Kleveland O, Stensæth KH, Opdahl A, Kløw NE, Seljeflot I, Andersen GØ, Wiseth R, Aukrust P, Gullestad L. Rationale for the ASSAIL-MI-trial: a randomised controlled trial designed to assess the effect of tocilizumab on myocardial salvage in patients with acute ST-elevation myocardial infarction (STEMI). Open Heart. 2019. 2019 Aug;46:264-273.6. DOI: 10.1136/openhrt-2019-001108. The article is included in the thesis. Also available at: https://doi.org/10.1136/openhrt-2019-001108 | |
| dc.relation.haspart | Paper II: Broch K, Anstensrud AK, Woxholt S, Sharma K, Tøllefsen IM, Bendz B, Aakhus S, Ueland T, Amundsen BH, Damås JK, Berg, ES, Bjørkelund E, Bendz C, Hopp E, Kleveland O, Stensæth KH, Opdahl A, Kløw NE, Seljeflot I, Andersen GØ, Wiseth R, Aukrust P, Gullestad L. Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute STSegment Elevation Myocardial Infarction. J Am Coll Cardiol. 2021 Apr 20;77(15) 1845-1855. DOI: 10.1016/j.jacc.2021.02.049. The article is included in the thesis. Also available at: https://doi.org/10.1016/j.jacc.2021.02.049 | |
| dc.relation.haspart | Paper III: Huse C, Anstensrud AK, Michelsen AE, Ueland T, Broch K, Woxholt S, Yang K, Sharma K, Tøllefsen IM, Bendz B, Amundsen BH, Damås JK, Berg ES, Bjørkelund E, Quiles-Jiménez A, Bjerkeli V, Bendz C, Kleveland O, Stensaeth KH, Opdahl A, Kløw NE, Andersen GØ, Wiseth R, Halvorsen B, Gullestad L, Seljeflot I, Aukrust P, Osnes L, Dahl TB. Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial. EBioMedicine 2022 Jun;80:104013. DOI: 10.1016/J.ebiom.2022.104013. The article is included in the thesis. Also available at: https://doi.org/10.1016/J.ebiom.2022.104013 | |
| dc.relation.haspart | Paper IV: Fosshaug LE, Colas RA, Anstensrud AK, Gregersen I, Nymo S, Sagen EL, Michelsen A, Vinge LE, Øie E, Gullestad L, Halvorsen B, Hansen TV, Aukrust P, Dalli J, Yndestad A. Early increase of specialised pro-resolving lipid mediators in patients with STelevation myocardial infarction. EBioMedicine 2019 Aug; 46:264-273. DOI: 10.1016/j.ebiom.2019.07.024. The article is included in the thesis. Also available at: https://doi.org/10.1016/j.ebiom.2019.07.024 | |
| dc.relation.uri | https://doi.org/10.1136/openhrt-2019-001108 | |
| dc.relation.uri | https://doi.org/10.1016/j.jacc.2021.02.049 | |
| dc.relation.uri | https://doi.org/10.1016/J.ebiom.2022.104013 | |
| dc.relation.uri | https://doi.org/10.1016/j.ebiom.2019.07.024 | |
| dc.title | Acute ST-elevation Myocardial Infarction and Interleukin-6 Inhibition Cardioprotection and Novel Therapeutic Strategies | en_US |
| dc.type | Doctoral thesis | en_US |
| dc.creator.author | Anstensrud, Anne Kristine | |
| dc.type.document | Doktoravhandling | en_US |