dc.date.accessioned | 2023-11-30T17:32:01Z | |
dc.date.available | 2023-11-30T17:32:01Z | |
dc.date.created | 2023-03-19T14:29:19Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Gudmundstuen, Anne Marte Efficace, Fabio Tjønnfjord, Geir Erland Skaarud, Kristin Aneta Joan Cottone, Francesco Hjermstad, Marianne Jensen Iversen, Per Ole . The prognostic value of patient-reported outcomes in allogeneic hematopoietic stem cell transplantation: exploratory analysis of a randomized nutrition intervention trial. Annals of Hematology. 2023, 102(4), 927-935 | |
dc.identifier.uri | http://hdl.handle.net/10852/106064 | |
dc.description.abstract | Whether patient-reported outcomes (PROs) can predict overall survival (OS) and non-relapse mortality (NRM) among recipients of allogeneic stem cell transplantation (allo-HSCT), is unclear. We performed an exploratory analysis of the prognostic value of patient-reported outcomes (PROs) among 117 recipients of allogeneic stem cell transplantation (allo-HSCT) who participated in a randomized nutrition intervention trial. Cox proportional hazards models were used to investigate possible associations between PROs collected pre-allo-HSCT (baseline) using scores from the EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30) and 1-year overall survival (OS), whereas logistic regression was used to study associations between these PROs and 1-year non-relapse mortality (NRM). Multivariable analyses indicated that only the Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI) and the European Bone Marrow Transplantation (EBMT) risk score were associated with 1-year OS. In the multivariable model including clinical-sociodemographic factors for 1-year NRM, our analysis showed that living alone (p=0.009), HCT-CI (p=0.016), EBMT risk score (p=0.002), and stem cell source (p=0.046) could be associated with 1-year NRM. Moreover, in the multivariable model, our analysis showed that only appetite loss from the QLQ-C30 was associated with 1-year NRM (p=0.026). In conclusion, in this specific setting, our analysis suggests that the commonly used HCT-CI and EBMT risk scores could be predictive for both 1-year OS and 1-year NRM, whereas baseline PROs in general were not. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | The prognostic value of patient-reported outcomes in allogeneic hematopoietic stem cell transplantation: exploratory analysis of a randomized nutrition intervention trial | |
dc.title.alternative | ENEngelskEnglishThe prognostic value of patient-reported outcomes in allogeneic hematopoietic stem cell transplantation: exploratory analysis of a randomized nutrition intervention trial | |
dc.type | Journal article | |
dc.creator.author | Gudmundstuen, Anne Marte | |
dc.creator.author | Efficace, Fabio | |
dc.creator.author | Tjønnfjord, Geir Erland | |
dc.creator.author | Skaarud, Kristin Aneta Joan | |
dc.creator.author | Cottone, Francesco | |
dc.creator.author | Hjermstad, Marianne Jensen | |
dc.creator.author | Iversen, Per Ole | |
cristin.unitcode | 185,90,0,0 | |
cristin.unitname | Universitetet i Oslo | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2135059 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Annals of Hematology&rft.volume=102&rft.spage=927&rft.date=2023 | |
dc.identifier.jtitle | Annals of Hematology | |
dc.identifier.volume | 102 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 927 | |
dc.identifier.endpage | 935 | |
dc.identifier.doi | https://doi.org/10.1007/s00277-023-05149-x | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0939-5555 | |
dc.type.version | PublishedVersion | |