dc.date.accessioned | 2023-11-17T16:28:43Z | |
dc.date.available | 2023-11-17T16:28:43Z | |
dc.date.created | 2023-09-20T09:43:05Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Nordén, Einar Sjaastad Veras, Ioanni Yadav, Prakash Løken, Kari Dishington, Hilde Thorstensen, Christian Sjaastad, Ivar Rasmussen, Henrik . Clinical efficacy of buprenorphine after oral dosing in rats undergoing major surgery. Laboratory Animals. 2023 | |
dc.identifier.uri | http://hdl.handle.net/10852/105914 | |
dc.description.abstract | Serum corticosterone, serum buprenorphine, body weight change, consumption of food and water and behaviour-based pain assessment were measured in catheterised and non-catheterised male Wistar rats undergoing myocardial infarct (MI) surgery under general anaesthesia following buprenorphine dosing by subcutaneous (Bup-SC, 0.05 mg/kg) and oral (Bup-O, 0.4 mg/kg) routes. Buprenorphine was dosed subcutaneously at half an hour before and 8, 16 and 24 hours after surgery (Bup-SC), orally at one hour before surgery (Bup-O1) or at one hour before and 12 hours after surgery (Bup-O2) in catheterised rats and at one hour before and 24 hours after surgery (Bup-O24) in non-catheterised rats. Serum corticosterone, body weight changes and food and water consumption were not significantly different between treatments in catheterised rats. Bup-SC resulted in rapidly decreasing serum concentrations below the clinically effective concentrations (1 ng/mL) already at two hours after the first dose. Bup-O provided significantly higher and slowly decreasing serum concentrations, at or above clinically effective concentrations, for 24 hours (Bup-O1) and 42 hours (Bup-O2) after surgery. In non-catheterised rats, body weight development and food consumption were significantly higher in Bup-O24 rats compared to Bup-SC rats. The results indicate that a SC buprenorphine dose of 0.05 mg/kg every eight hours provides long periods of serum concentrations below clinically effective levels, and that a higher dose and/or more frequent dosage are required to provide stable serum concentrations at or above clinically effective levels. A single oral buprenorphine dose of 0.4 mg/kg provides clinically effective and stable serum concentrations for 24 hours in rats after MI surgery. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Clinical efficacy of buprenorphine after oral dosing in rats undergoing major surgery | |
dc.title.alternative | ENEngelskEnglishClinical efficacy of buprenorphine after oral dosing in rats undergoing major surgery | |
dc.type | Journal article | |
dc.creator.author | Nordén, Einar Sjaastad | |
dc.creator.author | Veras, Ioanni | |
dc.creator.author | Yadav, Prakash | |
dc.creator.author | Løken, Kari | |
dc.creator.author | Dishington, Hilde | |
dc.creator.author | Thorstensen, Christian | |
dc.creator.author | Sjaastad, Ivar | |
dc.creator.author | Rasmussen, Henrik | |
cristin.unitcode | 185,53,15,10 | |
cristin.unitname | Institutt for eksperimentell medisinsk forskning | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2176848 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Laboratory Animals&rft.volume=&rft.spage=&rft.date=2023 | |
dc.identifier.jtitle | Laboratory Animals | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1177/00236772231178417 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0023-6772 | |
dc.type.version | PublishedVersion | |