dc.date.accessioned | 2023-11-17T16:20:59Z | |
dc.date.available | 2023-11-17T16:20:59Z | |
dc.date.created | 2023-07-26T15:53:15Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Mlakar, Vid Birkenæs, Viktoria Elvsåshagen, Torbjørn Ormerod, Monica Bettina E. Greenwood Quintana, Daniel Ueland, Torill Melle, Ingrid Lagerberg, Trine Vik Djurovic, Srdjan Martin-Ruiz, Carmen Steen, Nils Eiel Andreassen, Ole Aas, Monica . Telomere length and verbal learning in bipolar disorders. Journal of Affective Disorders. 2023, 339, 555-560 | |
dc.identifier.uri | http://hdl.handle.net/10852/105911 | |
dc.description.abstract | Introduction
Recent studies indicate accelerated ageing processes, shorter telomere length and poorer cognitive functioning in patients with bipolar disorder. The neurobiology underlying cognitive function in bipolar disorder is yet to be established. We anticipated that accelerated ageing as indicated by shortened telomere length, would be associated with reduced cognitive performance in bipolar disorder, particularly for ageing sensitive functions such as memory and learning.
Methods
The study consisted of 647 participants (bipolar disorder [n = 246] and healthy controls [n = 401]). All participants underwent a standardized neuropsychological test battery, including working memory, executive functioning, processing speed, verbal learning, and verbal memory. Leucocyte telomere length was measured via blood and determined by quantitative real-time Polymerase Chain Reaction (qPCR) providing a telomere to single copy ratio (T/S ratio). The T/S ratio was used as an estimate of the mean telomere length of each participant. All analyses were adjusted for medication, Daily Defined Dose (DDD), chronological age, sex, and ethnicity.
Results
Patients had shorter telomere lengths than healthy controls (Cohen's d = 0.11, p = 0.01). Within patients', a positive association was observed for verbal learning and telomere length (β = 0.14, p = 0.025), along with a trend for verbal memory and telomere length (β = 0.11, p = 0.07). No other associations were observed for telomere length and cognitive functioning in the patient or the control group (p > 0.1).
Conclusion
Our study may suggest poorer brain health in bipolar disorder as indexed by shorter telomere length and reduced learning correlates. However, the role of telomere length on cognitive functioning in bipolar disorder seems limited. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Telomere length and verbal learning in bipolar disorders | |
dc.title.alternative | ENEngelskEnglishTelomere length and verbal learning in bipolar disorders | |
dc.type | Journal article | |
dc.creator.author | Mlakar, Vid | |
dc.creator.author | Birkenæs, Viktoria | |
dc.creator.author | Elvsåshagen, Torbjørn | |
dc.creator.author | Ormerod, Monica Bettina E. Greenwood | |
dc.creator.author | Quintana, Daniel | |
dc.creator.author | Ueland, Torill | |
dc.creator.author | Melle, Ingrid | |
dc.creator.author | Lagerberg, Trine Vik | |
dc.creator.author | Djurovic, Srdjan | |
dc.creator.author | Martin-Ruiz, Carmen | |
dc.creator.author | Steen, Nils Eiel | |
dc.creator.author | Andreassen, Ole | |
dc.creator.author | Aas, Monica | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | NORMENT part UiO | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2163706 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Affective Disorders&rft.volume=339&rft.spage=555&rft.date=2023 | |
dc.identifier.jtitle | Journal of Affective Disorders | |
dc.identifier.volume | 339 | |
dc.identifier.startpage | 555 | |
dc.identifier.endpage | 560 | |
dc.identifier.doi | https://doi.org/10.1016/j.jad.2023.07.087 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0165-0327 | |
dc.type.version | PublishedVersion | |
dc.relation.project | EC/HEU/964874 | |