Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)
dc.date.accessioned | 2023-11-15T16:37:14Z | |
dc.date.available | 2023-11-15T16:37:14Z | |
dc.date.created | 2023-10-31T09:54:20Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Anthon, Carl Thomas Pène, Frédéric Perner, Anders Azoulay, Elie Puxty, Kathryn Van De Louw, Andry Barratt-Due, Andreas Chawla, Sanjay Castro, Pedro Póvoa, Pedro Coelho, Luis Metaxa, Victoria Kochanek, Matthias Liebregts, Tobias Kander, Thomas Hästbacka, Johanna Andreasen, Jo Bønding Péju, Edwige Nielsen, Lene Bjerregaard Hvas, Christine Lodberg Dufranc, Etienne Canet, Emmanuel Lundqvist, Linda Wright, Christopher John Schmidt, Julien Uhel, Fabrice Ait-Oufella, Hafid Krag, Mette Cos Badia, Elisabet Díaz-Lagares, Cándido Menat, Sophie Voiriot, Guillaume Clausen, Niels Erikstrup Lorentzen, Kristian Kvåle, Reidar Hildebrandt, Thomas Holten, Aleksander Rygh Strand, Kristian Tzalavras, Asterios Bestle, Morten Heiberg Klepstad, Pål Fernandez, Sara Vimpere, Damien Paulino, Carolina Graça, Carina Lueck, Catherina Juhl, Christian Svendsen Costa, Carolina Bådstøløkken, Per Martin Miranda, Teresa Lêdo, Lia Susana Aires Sousa Torres, Joao Carlos Granholm, Anders Møller, Morten Hylander Russell, Lene Khalil, Ahmed Yehia, Ahmed Salem, Haney Farahat, Hesham Sudevan, Manu Biggart, Melissa Fatima, Nirmeen Elkhonezy, Mohammed Bunzel, Anne-Marie Siegumfeldt, Rine M. Vestergaard, Stine R. Pelle, Juliette Lê, Minh-Pierre Vigneron, Clara Bertrix, Morgane Cirera, Paul Laghlam, Driss Bredin, Swann Marin, Nathalie Toppenberg, Maria Benelli, Brice Seguin, Amélie Garret, Charlotte Guillotin, Florian Blonz, Gauthier Lascarrou, Jean-Baptiste Lemarie, Jérémie Desmedt, Luc Agbakou, Maïté Carpentier, Mathieu Martin, Maëlle Benkalfate, Naïla Zambon, Olivier Decamps, Paul Wilquin, Pauline L. Benguerfi, Soraya Gardner, John Remor, Natalie Carr, Sheila Yang, Gloria Gernez, Coralie Thiry, Ingrid Missri, Louai Denneborg, Moritz K. G. Brown, Katherine Casares, Vanessa Sivula, Mirka Lappi, Elina Pettilä, Leena Heinonen, Jonna Saario, Minttu Mecheri, Manal K. Elabbadi, Alezandre Desnos, Cyrielle Lafarge, Antoine Mghirbi, Olfa Sjøbø, Brit Ågot Christoffersen, Cecilie Bestle, Frederik H. Lemos, Claudia Gonçalves, Cristiana V. Jacinto, Nuno M. B. Anselmo, Monica P. Hoeper, Marius M. Hoff, Marja Simões Freire, Pedro M. . Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU). Intensive Care Medicine. 2023 | |
dc.identifier.uri | http://hdl.handle.net/10852/105860 | |
dc.description.abstract | Purpose Thrombocytopenia (platelet count < 150 × 109/L) is common in intensive care unit (ICU) patients and is likely associated with worse outcomes. In this study we present international contemporary data on thrombocytopenia in ICU patients. Methods We conducted a prospective cohort study in adult ICU patients in 52 ICUs across 10 countries. We assessed frequencies of thrombocytopenia, use of platelet transfusions and clinical outcomes including mortality. We evaluated pre-selected potential risk factors for the development of thrombocytopenia during ICU stay and associations between thrombocytopenia at ICU admission and 90-day mortality using pre-specified logistic regression analyses. Results We analysed 1166 ICU patients; the median age was 63 years and 39.5% were female. Overall, 43.2% (95% confidence interval (CI) 40.4–46.1) had thrombocytopenia; 23.4% (20–26) had thrombocytopenia at ICU admission, and 19.8% (17.6–22.2) developed thrombocytopenia during their ICU stay. Absence of acquired immune deficiency syndrome (AIDS), non-cancer-related immune deficiency, liver failure, male sex, septic shock, and bleeding at ICU admission were associated with the development of thrombocytopenia during ICU stay. Among patients with thrombocytopenia, 22.6% received platelet transfusion(s), and 64.3% of in-ICU transfusions were prophylactic. Patients with thrombocytopenia had higher occurrences of bleeding and death, fewer days alive without the use of life-support, and fewer days alive and out of hospital. Thrombocytopenia at ICU admission was associated with 90-day mortality (adjusted odds ratio 1.7; 95% CI 1.19–2.42). Conclusion Thrombocytopenia occurred in 43% of critically ill patients and was associated with worse outcomes including increased mortality. Platelet transfusions were given to 23% of patients with thrombocytopenia and most were prophylactic. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.title | Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU) | |
dc.title.alternative | ENEngelskEnglishThrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU) | |
dc.type | Journal article | |
dc.creator.author | Anthon, Carl Thomas | |
dc.creator.author | Pène, Frédéric | |
dc.creator.author | Perner, Anders | |
dc.creator.author | Azoulay, Elie | |
dc.creator.author | Puxty, Kathryn | |
dc.creator.author | Van De Louw, Andry | |
dc.creator.author | Barratt-Due, Andreas | |
dc.creator.author | Chawla, Sanjay | |
dc.creator.author | Castro, Pedro | |
dc.creator.author | Póvoa, Pedro | |
dc.creator.author | Coelho, Luis | |
dc.creator.author | Metaxa, Victoria | |
dc.creator.author | Kochanek, Matthias | |
dc.creator.author | Liebregts, Tobias | |
dc.creator.author | Kander, Thomas | |
dc.creator.author | Hästbacka, Johanna | |
dc.creator.author | Andreasen, Jo Bønding | |
dc.creator.author | Péju, Edwige | |
dc.creator.author | Nielsen, Lene Bjerregaard | |
dc.creator.author | Hvas, Christine Lodberg | |
dc.creator.author | Dufranc, Etienne | |
dc.creator.author | Canet, Emmanuel | |
dc.creator.author | Lundqvist, Linda | |
dc.creator.author | Wright, Christopher John | |
dc.creator.author | Schmidt, Julien | |
dc.creator.author | Uhel, Fabrice | |
dc.creator.author | Ait-Oufella, Hafid | |
dc.creator.author | Krag, Mette | |
dc.creator.author | Cos Badia, Elisabet | |
dc.creator.author | Díaz-Lagares, Cándido | |
dc.creator.author | Menat, Sophie | |
dc.creator.author | Voiriot, Guillaume | |
dc.creator.author | Clausen, Niels Erikstrup | |
dc.creator.author | Lorentzen, Kristian | |
dc.creator.author | Kvåle, Reidar | |
dc.creator.author | Hildebrandt, Thomas | |
dc.creator.author | Holten, Aleksander Rygh | |
dc.creator.author | Strand, Kristian | |
dc.creator.author | Tzalavras, Asterios | |
dc.creator.author | Bestle, Morten Heiberg | |
dc.creator.author | Klepstad, Pål | |
dc.creator.author | Fernandez, Sara | |
dc.creator.author | Vimpere, Damien | |
dc.creator.author | Paulino, Carolina | |
dc.creator.author | Graça, Carina | |
dc.creator.author | Lueck, Catherina | |
dc.creator.author | Juhl, Christian Svendsen | |
dc.creator.author | Costa, Carolina | |
dc.creator.author | Bådstøløkken, Per Martin | |
dc.creator.author | Miranda, Teresa | |
dc.creator.author | Lêdo, Lia Susana Aires | |
dc.creator.author | Sousa Torres, Joao Carlos | |
dc.creator.author | Granholm, Anders | |
dc.creator.author | Møller, Morten Hylander | |
dc.creator.author | Russell, Lene | |
dc.creator.author | Khalil, Ahmed | |
dc.creator.author | Yehia, Ahmed | |
dc.creator.author | Salem, Haney | |
dc.creator.author | Farahat, Hesham | |
dc.creator.author | Sudevan, Manu | |
dc.creator.author | Biggart, Melissa | |
dc.creator.author | Fatima, Nirmeen | |
dc.creator.author | Elkhonezy, Mohammed | |
dc.creator.author | Bunzel, Anne-Marie | |
dc.creator.author | Siegumfeldt, Rine M. | |
dc.creator.author | Vestergaard, Stine R. | |
dc.creator.author | Pelle, Juliette | |
dc.creator.author | Lê, Minh-Pierre | |
dc.creator.author | Vigneron, Clara | |
dc.creator.author | Bertrix, Morgane | |
dc.creator.author | Cirera, Paul | |
dc.creator.author | Laghlam, Driss | |
dc.creator.author | Bredin, Swann | |
dc.creator.author | Marin, Nathalie | |
dc.creator.author | Toppenberg, Maria | |
dc.creator.author | Benelli, Brice | |
dc.creator.author | Seguin, Amélie | |
dc.creator.author | Garret, Charlotte | |
dc.creator.author | Guillotin, Florian | |
dc.creator.author | Blonz, Gauthier | |
dc.creator.author | Lascarrou, Jean-Baptiste | |
dc.creator.author | Lemarie, Jérémie | |
dc.creator.author | Desmedt, Luc | |
dc.creator.author | Agbakou, Maïté | |
dc.creator.author | Carpentier, Mathieu | |
dc.creator.author | Martin, Maëlle | |
dc.creator.author | Benkalfate, Naïla | |
dc.creator.author | Zambon, Olivier | |
dc.creator.author | Decamps, Paul | |
dc.creator.author | Wilquin, Pauline L. | |
dc.creator.author | Benguerfi, Soraya | |
dc.creator.author | Gardner, John | |
dc.creator.author | Remor, Natalie | |
dc.creator.author | Carr, Sheila | |
dc.creator.author | Yang, Gloria | |
dc.creator.author | Gernez, Coralie | |
dc.creator.author | Thiry, Ingrid | |
dc.creator.author | Missri, Louai | |
dc.creator.author | Denneborg, Moritz K. G. | |
dc.creator.author | Brown, Katherine | |
dc.creator.author | Casares, Vanessa | |
dc.creator.author | Sivula, Mirka | |
dc.creator.author | Lappi, Elina | |
dc.creator.author | Pettilä, Leena | |
dc.creator.author | Heinonen, Jonna | |
dc.creator.author | Saario, Minttu | |
dc.creator.author | Mecheri, Manal K. | |
dc.creator.author | Elabbadi, Alezandre | |
dc.creator.author | Desnos, Cyrielle | |
dc.creator.author | Lafarge, Antoine | |
dc.creator.author | Mghirbi, Olfa | |
dc.creator.author | Sjøbø, Brit Ågot | |
dc.creator.author | Christoffersen, Cecilie | |
dc.creator.author | Bestle, Frederik H. | |
dc.creator.author | Lemos, Claudia | |
dc.creator.author | Gonçalves, Cristiana V. | |
dc.creator.author | Jacinto, Nuno M. B. | |
dc.creator.author | Anselmo, Monica P. | |
dc.creator.author | Hoeper, Marius M. | |
dc.creator.author | Hoff, Marja | |
dc.creator.author | Simões Freire, Pedro M. | |
cristin.unitcode | 185,53,11,14 | |
cristin.unitname | Infeksjonsmedisinsk avdeling | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2190329 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Intensive Care Medicine&rft.volume=&rft.spage=&rft.date=2023 | |
dc.identifier.jtitle | Intensive Care Medicine | |
dc.identifier.volume | 49 | |
dc.identifier.issue | 11 | |
dc.identifier.startpage | 1327 | |
dc.identifier.endpage | 1338 | |
dc.identifier.pagecount | 0 | |
dc.identifier.doi | https://doi.org/10.1007/s00134-023-07225-2 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0342-4642 | |
dc.type.version | PublishedVersion |
Files in this item
Appears in the following Collection
-
Institutt for klinisk medisin [10814]
-
CRIStin høstingsarkiv [31446]