dc.date.accessioned | 2023-11-10T17:36:20Z | |
dc.date.available | 2023-11-10T17:36:20Z | |
dc.date.created | 2023-08-23T10:57:58Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Thorsen, Inga Strand Bleskestad, Inger Hjørdis Åsberg, Anders Jonsson, Grete Skadberg, Øyvind Heldal, Kristian Gøransson, Lasse Gunnar . Klotho and Fibroblast Growth Factor 23 Are Independent of Vitamin D, and Unlike Vitamin D, Are Not Associated With Graft- and Patient Survival After Kidney Transplantation. Transplantation direct. 2023, 9(9) | |
dc.identifier.uri | http://hdl.handle.net/10852/105783 | |
dc.description.abstract | Background.
Short-term survival after kidney transplantation is excellent but long-term survival remains suboptimal. The aim of the study was to explore the relationship between soluble α-Klotho (sKlotho) and intact fibroblast growth factor 23 (iFGF23) measured 8 wk and 1 y posttransplant with long-term graft- and patient survival in a cohort of kidney transplant recipients with deficient and nondeficient vitamin D (25[OH]D) levels.
Methods.
Vitamin D, sKlotho, and iFGF23 were measured 8 wk and 1 y posttransplant in 132 recipients transplanted between November 2012 and October 2013.
Results.
Of the 132 kidney transplant recipients, 49 had deficient vitamin D levels (<30 nmol/L) and 83 had nondeficient vitamin D levels (≥30 nmol/L) at 8 wk posttransplant. The mean age was 51 y and the median follow-up was 7.4 y. At 1 y posttransplant, vitamin D increased significantly. There were no significant differences in sKlotho or iFGF23 levels between the 2 vitamin D groups neither at 8 wk nor 1 y. sKlotho increased significantly and iFGF23 decreased significantly in the whole cohort. During the follow-up, there were 36 graft losses (27%) and 27 deaths (20%). Ninety-four percent of the transplant recipients with nondeficient vitamin D levels were alive with a well-functioning graft after 5 y using Kaplan-Meier survival estimates, compared with 84% of the patients with deficient vitamin D levels (P = 0.014). Klotho and FGF23 levels did not influence graft- and patient survival.
Conclusions.
In this nationwide cohort of kidney transplant recipients, long-term graft- and patient survival were significantly better in patients with vitamin D ≥30 nmol/L 8 wk posttransplant compared with those with vitamin D <30 nmol/L. sKlotho levels increased and iFGF23 levels decreased from 8 wk to 1 y posttransplant. Klotho and FGF23 levels were not associated with graft- and patient survival. | |
dc.language | EN | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Klotho and Fibroblast Growth Factor 23 Are Independent of Vitamin D, and Unlike Vitamin D, Are Not Associated With Graft- and Patient Survival After Kidney Transplantation | |
dc.title.alternative | ENEngelskEnglishKlotho and Fibroblast Growth Factor 23 Are Independent of Vitamin D, and Unlike Vitamin D, Are Not Associated With Graft- and Patient Survival After Kidney Transplantation | |
dc.type | Journal article | |
dc.creator.author | Thorsen, Inga Strand | |
dc.creator.author | Bleskestad, Inger Hjørdis | |
dc.creator.author | Åsberg, Anders | |
dc.creator.author | Jonsson, Grete | |
dc.creator.author | Skadberg, Øyvind | |
dc.creator.author | Heldal, Kristian | |
dc.creator.author | Gøransson, Lasse Gunnar | |
cristin.unitcode | 185,15,23,30 | |
cristin.unitname | Seksjon for farmakologi og farmasøytisk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2168954 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Transplantation direct&rft.volume=9&rft.spage=&rft.date=2023 | |
dc.identifier.jtitle | Transplantation direct | |
dc.identifier.volume | 9 | |
dc.identifier.issue | 9 | |
dc.identifier.pagecount | 8 | |
dc.identifier.doi | https://doi.org/10.1097/TXD.0000000000001522 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2373-8731 | |
dc.type.version | PublishedVersion | |
cristin.articleid | e1522 | |