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dc.date.accessioned2023-11-02T16:26:29Z
dc.date.available2023-11-02T16:26:29Z
dc.date.created2023-07-11T09:57:50Z
dc.date.issued2023
dc.identifier.citationFlaaten, Camilla Bärthel Melle, Ingrid Bjella, Thomas Engen, Magnus Johan Åsbø, Gina Wold, Kristin Fjelnseth Widing, Line Hustad Gardsjord, Erlend Strand Øie, Merete Glenne Lyngstad, Siv Hege Haatveit, Beathe Simonsen, Carmen Ueland, Torill . Long-term course of cognitive functioning in bipolar disorder: A ten-year follow-up study. Bipolar Disorders. 2023
dc.identifier.urihttp://hdl.handle.net/10852/105660
dc.description.abstractAbstract Introduction Cognitive impairments are common in bipolar disorder (BD), but the long‐term course remains understudied. Longitudinal data on cognitive functioning from the start of the first treatment could help clarify pathophysiological processes that shape the illness outcome. We here aim to investigate the 10‐year cognitive course in BD compared to healthy controls (HC) and the effects of clinical symptoms on cognitive trajectories. Methods Fifty‐six BD participants recruited within their first year of treatment and 108 HC completed clinical and cognitive assessments at baseline and 10‐year follow‐up. We derived eight cognitive domain scores and a cognitive composite score, which were further investigated using linear mixed model analyses. Correlation analyses were used to assess associations between the composite score and depressive, manic and psychotic symptoms. Results BD participants performed poorer than HCs in all domains except mental speed and verbal fluency. Verbal learning and memory, verbal fluency and the composite score improved over time in both BD participants and HC, while short‐term memory, mental speed, psychomotor speed and working memory were stable. We found no significant correlations between cognition and symptom level at either time point in BD participants. Conclusions We found evidence of long‐term cognitive stability or improvement in BD participants from first treatment to 10‐year follow‐up. Though the BD group was impaired in all domains except mental speed and verbal fluency, the change in cognitive functioning was parallel to that of HCs. These findings are not consistent with the notion of neuroprogression in BD.
dc.languageEN
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleLong-term course of cognitive functioning in bipolar disorder: A ten-year follow-up study
dc.title.alternativeENEngelskEnglishLong-term course of cognitive functioning in bipolar disorder: A ten-year follow-up study
dc.typeJournal article
dc.creator.authorFlaaten, Camilla Bärthel
dc.creator.authorMelle, Ingrid
dc.creator.authorBjella, Thomas
dc.creator.authorEngen, Magnus Johan
dc.creator.authorÅsbø, Gina
dc.creator.authorWold, Kristin Fjelnseth
dc.creator.authorWiding, Line Hustad
dc.creator.authorGardsjord, Erlend Strand
dc.creator.authorØie, Merete Glenne
dc.creator.authorLyngstad, Siv Hege
dc.creator.authorHaatveit, Beathe
dc.creator.authorSimonsen, Carmen
dc.creator.authorUeland, Torill
cristin.unitcode185,53,10,70
cristin.unitnameNORMENT part UiO
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2
dc.identifier.cristin2161873
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bipolar Disorders&rft.volume=&rft.spage=&rft.date=2023
dc.identifier.jtitleBipolar Disorders
dc.identifier.pagecount0
dc.identifier.doihttps://doi.org/10.1111/bdi.13364
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1398-5647
dc.type.versionPublishedVersion


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