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dc.date.accessioned2023-09-22T16:18:41Z
dc.date.available2023-09-22T16:18:41Z
dc.date.created2023-03-25T14:26:40Z
dc.date.issued2023
dc.identifier.citationAlmdahl, Ina Selseth Martinussen, Liva Jenny Ousdal, Olga Therese Kraus, Miroslawa Sowa, Piotr Agartz, Ingrid Korsnes, Maria Stylianou . Task-based functional connectivity reveals aberrance with the salience network during emotional interference in late-life depression. Aging & Mental Health. 2023
dc.identifier.urihttp://hdl.handle.net/10852/105278
dc.description.abstractObjectives Late-life depression (LLD) is a common and debilitating disorder. Previously, resting-state studies have revealed abnormal functional connectivity (FC) of brain networks in LLD. Since LLD is associated with emotional-cognitive control deficits, the aim of this study was to compare FC of large-scale brain networks in older adults with and without a history of LLD during a cognitive control task with emotional stimuli. Methods Cross-sectional case-control study. Twenty participants diagnosed with LLD and 37 never-depressed adults 60–88 years of age underwent functional magnetic resonance imaging during an emotional Stroop task. Network-region-to-region FC was assessed with seed regions in the default mode, the frontoparietal, the dorsal attention, and the salience networks. Results FC between salience and sensorimotor network regions and between salience and dorsal attention network regions were reduced in LLD patients compared to controls during the processing of incongruent emotional stimuli. The normally positive FC between these networks were negative in LLD patients and inversely correlated with vascular risk and white matter hyperintensities. Conclusions Emotional-cognitive control in LLD is associated with aberrant functional coupling between salience and other networks. This expands on the network-based LLD model and proposes the salience network as a target for future interventions.
dc.languageEN
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleTask-based functional connectivity reveals aberrance with the salience network during emotional interference in late-life depression
dc.title.alternativeENEngelskEnglishTask-based functional connectivity reveals aberrance with the salience network during emotional interference in late-life depression
dc.typeJournal article
dc.creator.authorAlmdahl, Ina Selseth
dc.creator.authorMartinussen, Liva Jenny
dc.creator.authorOusdal, Olga Therese
dc.creator.authorKraus, Miroslawa
dc.creator.authorSowa, Piotr
dc.creator.authorAgartz, Ingrid
dc.creator.authorKorsnes, Maria Stylianou
cristin.unitcode185,50,0,0
cristin.unitnameDet medisinske fakultet
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.cristin2136907
dc.identifier.bibliographiccitationinfo:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Aging & Mental Health&rft.volume=&rft.spage=&rft.date=2023
dc.identifier.jtitleAging & Mental Health
dc.identifier.volume27
dc.identifier.issue10
dc.identifier.startpage2043
dc.identifier.endpage2051
dc.identifier.pagecount0
dc.identifier.doihttps://doi.org/10.1080/13607863.2023.2179972
dc.type.documentTidsskriftartikkel
dc.type.peerreviewedPeer reviewed
dc.source.issn1360-7863
dc.type.versionPublishedVersion


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