Effects of urban living environments on mental health in adults
dc.date.accessioned | 2023-09-15T16:25:30Z | |
dc.date.available | 2023-09-15T16:25:30Z | |
dc.date.created | 2023-07-04T10:51:43Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Xu, Jiayuan Liu, Nana Polemiti, Elli Garcia-Mondragon, Liliana Tang, Jie Liu, Xiaoxuan Lett, Tristram Yu, Le Nöthen, Markus M. Feng, Jianfeng Yu, Chunshui Marquand, Andre Schumann, Gunter Walter, Henrik Heinz, Andreas Ralser, Markus Twardziok, Sven Vaidya, Nilakshi Serin, Emin Jentsch, Marcel Hitchen, Esther Eils, Roland Taron, Ulrike-Helene Schütz, Tatjana Schepanski, Kerstin Banks, Jamie Banaschewski, Tobias Jansone, Karina Christmann, Nina Meyer-Lindenberg, Andreas Tost, Heike Holz, Nathalie Schwarz, Emanuel Stringaris, Argyris Neidhart, Maja Nees, Frauke Siehl, Sebastian Andreassen, Ole Westlye, Lars Tjelta van der Meer, Dennis Fernandez-Cabello, Sara Kjelkenes, Rikka Ask, Helga Rapp, Michael Tschorn, Mira Böttger, Sarah Jane Novarino, Gaia Marr, Lena Slater, Mel Viapiana, Guillem Feixas Orosa, Francisco Eiroa Gallego, Jaime Pastor, Alvaro Forstner, Andreas Hoffmann, Per M. Nöthen, Markus J. Forstner, Andreas Claus, Isabelle Miller, Abbi Heilmann-Heimbach, Stefanie Sommer, Peter Boye, Mona Wilbertz, Johannes Schmitt, Karen Jirsa, Viktor Petkoski, Spase Pitel, Séverine Otten, Lisa Athanasiadis, Anastasios-Polykarpos Pearmund, Charlie Spanlang, Bernhard Alvarez, Elena Sanchez, Mavi Giner, Arantxa Hese, Sören Renner, Paul Jia, Tianye Gong, Yanting Xia, Yunman Chang, Xiao Calhoun, Vince Liu, Jingyu Thompson, Paul Clinton, Nicholas Desrivieres, Sylvane H. Young, Allan Stahl, Bernd Ogoh, George . Effects of urban living environments on mental health in adults. Nature Medicine. 2023, 29, 1456-1467 | |
dc.identifier.uri | http://hdl.handle.net/10852/105041 | |
dc.description.abstract | Abstract Urban-living individuals are exposed to many environmental factors that may combine and interact to influence mental health. While individual factors of an urban environment have been investigated in isolation, no attempt has been made to model how complex, real-life exposure to living in the city relates to brain and mental health, and how this is moderated by genetic factors. Using the data of 156,075 participants from the UK Biobank, we carried out sparse canonical correlation analyses to investigate the relationships between urban environments and psychiatric symptoms. We found an environmental profile of social deprivation, air pollution, street network and urban land-use density that was positively correlated with an affective symptom group ( r = 0.22, P perm < 0.001), mediated by brain volume differences consistent with reward processing, and moderated by genes enriched for stress response, including CRHR1 , explaining 2.01% of the variance in brain volume differences. Protective factors such as greenness and generous destination accessibility were negatively correlated with an anxiety symptom group ( r = 0.10, P perm < 0.001), mediated by brain regions necessary for emotion regulation and moderated by EXD3 , explaining 1.65% of the variance. The third urban environmental profile was correlated with an emotional instability symptom group ( r = 0.03, P perm < 0.001). Our findings suggest that different environmental profiles of urban living may influence specific psychiatric symptom groups through distinct neurobiological pathways. | |
dc.language | EN | |
dc.publisher | Nature Portfolio | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Effects of urban living environments on mental health in adults | |
dc.title.alternative | ENEngelskEnglishEffects of urban living environments on mental health in adults | |
dc.type | Journal article | |
dc.creator.author | Xu, Jiayuan | |
dc.creator.author | Liu, Nana | |
dc.creator.author | Polemiti, Elli | |
dc.creator.author | Garcia-Mondragon, Liliana | |
dc.creator.author | Tang, Jie | |
dc.creator.author | Liu, Xiaoxuan | |
dc.creator.author | Lett, Tristram | |
dc.creator.author | Yu, Le | |
dc.creator.author | Nöthen, Markus M. | |
dc.creator.author | Feng, Jianfeng | |
dc.creator.author | Yu, Chunshui | |
dc.creator.author | Marquand, Andre | |
dc.creator.author | Schumann, Gunter | |
dc.creator.author | Walter, Henrik | |
dc.creator.author | Heinz, Andreas | |
dc.creator.author | Ralser, Markus | |
dc.creator.author | Twardziok, Sven | |
dc.creator.author | Vaidya, Nilakshi | |
dc.creator.author | Serin, Emin | |
dc.creator.author | Jentsch, Marcel | |
dc.creator.author | Hitchen, Esther | |
dc.creator.author | Eils, Roland | |
dc.creator.author | Taron, Ulrike-Helene | |
dc.creator.author | Schütz, Tatjana | |
dc.creator.author | Schepanski, Kerstin | |
dc.creator.author | Banks, Jamie | |
dc.creator.author | Banaschewski, Tobias | |
dc.creator.author | Jansone, Karina | |
dc.creator.author | Christmann, Nina | |
dc.creator.author | Meyer-Lindenberg, Andreas | |
dc.creator.author | Tost, Heike | |
dc.creator.author | Holz, Nathalie | |
dc.creator.author | Schwarz, Emanuel | |
dc.creator.author | Stringaris, Argyris | |
dc.creator.author | Neidhart, Maja | |
dc.creator.author | Nees, Frauke | |
dc.creator.author | Siehl, Sebastian | |
dc.creator.author | Andreassen, Ole | |
dc.creator.author | Westlye, Lars Tjelta | |
dc.creator.author | van der Meer, Dennis | |
dc.creator.author | Fernandez-Cabello, Sara | |
dc.creator.author | Kjelkenes, Rikka | |
dc.creator.author | Ask, Helga | |
dc.creator.author | Rapp, Michael | |
dc.creator.author | Tschorn, Mira | |
dc.creator.author | Böttger, Sarah Jane | |
dc.creator.author | Novarino, Gaia | |
dc.creator.author | Marr, Lena | |
dc.creator.author | Slater, Mel | |
dc.creator.author | Viapiana, Guillem Feixas | |
dc.creator.author | Orosa, Francisco Eiroa | |
dc.creator.author | Gallego, Jaime | |
dc.creator.author | Pastor, Alvaro | |
dc.creator.author | Forstner, Andreas | |
dc.creator.author | Hoffmann, Per | |
dc.creator.author | M. Nöthen, Markus | |
dc.creator.author | J. Forstner, Andreas | |
dc.creator.author | Claus, Isabelle | |
dc.creator.author | Miller, Abbi | |
dc.creator.author | Heilmann-Heimbach, Stefanie | |
dc.creator.author | Sommer, Peter | |
dc.creator.author | Boye, Mona | |
dc.creator.author | Wilbertz, Johannes | |
dc.creator.author | Schmitt, Karen | |
dc.creator.author | Jirsa, Viktor | |
dc.creator.author | Petkoski, Spase | |
dc.creator.author | Pitel, Séverine | |
dc.creator.author | Otten, Lisa | |
dc.creator.author | Athanasiadis, Anastasios-Polykarpos | |
dc.creator.author | Pearmund, Charlie | |
dc.creator.author | Spanlang, Bernhard | |
dc.creator.author | Alvarez, Elena | |
dc.creator.author | Sanchez, Mavi | |
dc.creator.author | Giner, Arantxa | |
dc.creator.author | Hese, Sören | |
dc.creator.author | Renner, Paul | |
dc.creator.author | Jia, Tianye | |
dc.creator.author | Gong, Yanting | |
dc.creator.author | Xia, Yunman | |
dc.creator.author | Chang, Xiao | |
dc.creator.author | Calhoun, Vince | |
dc.creator.author | Liu, Jingyu | |
dc.creator.author | Thompson, Paul | |
dc.creator.author | Clinton, Nicholas | |
dc.creator.author | Desrivieres, Sylvane | |
dc.creator.author | H. Young, Allan | |
dc.creator.author | Stahl, Bernd | |
dc.creator.author | Ogoh, George | |
cristin.unitcode | 185,53,10,70 | |
cristin.unitname | NORMENT part UiO | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2160551 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Medicine&rft.volume=29&rft.spage=1456&rft.date=2023 | |
dc.identifier.jtitle | Nature Medicine | |
dc.identifier.volume | 29 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 1456 | |
dc.identifier.endpage | 1467 | |
dc.identifier.doi | https://doi.org/10.1038/s41591-023-02365-w | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1078-8956 | |
dc.type.version | PublishedVersion | |
dc.relation.project | ERC/695313 |
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Psykologisk institutt [4401]
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Institutt for klinisk medisin [10783]
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CRIStin høstingsarkiv [31417]