The shape of chromatin: insights from computational recognition of geometric patterns in Hi-C data

dc.date.accessioned	2023-09-06T16:12:24Z
dc.date.available	2023-09-06T16:12:24Z
dc.date.created	2023-08-31T10:24:12Z
dc.date.issued	2023
dc.identifier.citation	Raffo, Andrea Paulsen, Jonas . The shape of chromatin: insights from computational recognition of geometric patterns in Hi-C data. Briefings in Bioinformatics. 2023
dc.identifier.uri	http://hdl.handle.net/10852/104486
dc.description.abstract	The three-dimensional organization of chromatin plays a crucial role in gene regulation and cellular processes like deoxyribonucleic acid (DNA) transcription, replication and repair. Hi-C and related techniques provide detailed views of spatial proximities within the nucleus. However, data analysis is challenging partially due to a lack of well-defined, underpinning mathematical frameworks. Recently, recognizing and analyzing geometric patterns in Hi-C data has emerged as a powerful approach. This review provides a summary of algorithms for automatic recognition and analysis of geometric patterns in Hi-C data and their correspondence with chromatin structure. We classify existing algorithms on the basis of the data representation and pattern recognition paradigm they make use of. Finally, we outline some of the challenges ahead and promising future directions.
dc.description.abstract	The shape of chromatin: insights from computational recognition of geometric patterns in Hi-C data
dc.language	EN
dc.rights	Attribution 4.0 International
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/
dc.title	The shape of chromatin: insights from computational recognition of geometric patterns in Hi-C data
dc.title.alternative	ENEngelskEnglishThe shape of chromatin: insights from computational recognition of geometric patterns in Hi-C data
dc.type	Journal article
dc.creator.author	Raffo, Andrea
dc.creator.author	Paulsen, Jonas
cristin.unitcode	185,15,29,60
cristin.unitname	Seksjon for genetikk og evolusjonsbiologi
cristin.ispublished	true
cristin.fulltext	original
cristin.qualitycode	2
dc.identifier.cristin	2171282
dc.identifier.bibliographiccitation	info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Briefings in Bioinformatics&rft.volume=&rft.spage=&rft.date=2023
dc.identifier.jtitle	Briefings in Bioinformatics
dc.identifier.doi	https://doi.org/10.1093/bib/bbad302
dc.type.document	Tidsskriftartikkel
dc.type.peerreviewed	Peer reviewed
dc.source.issn	1467-5463
dc.type.version	PublishedVersion
cristin.articleid	bbad302
dc.relation.project	NFR/324137