dc.date.accessioned | 2023-07-06T15:32:38Z | |
dc.date.available | 2023-07-06T15:32:38Z | |
dc.date.created | 2023-06-29T14:01:19Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Hall, Amber M. Keil, Alexander P. Choi, Giehae Ramos, Amanda M. Richardson, David B. Olshan, Andrew F. Martin, Chantel L. Villanger, Gro Dehli Reichborn-Kjennerud, Ted Zeiner, Pål Øvergaard, Kristin Sakhi, Amrit Kaur Thomsen, Cathrine Aase, Heidi Engel, Stephanie M. . Prenatal organophosphate ester exposure and executive function in Norwegian preschoolers. Environmental Epidemiology. 2023, 7(3), 1-9 | |
dc.identifier.uri | http://hdl.handle.net/10852/102645 | |
dc.description.abstract | Background:
Organophosphate esters (OPEs) are ubiquitous chemicals, used as flame retardants and plasticizers. OPE usage has increased over time as a substitute for other controlled compounds. This study investigates the impact of prenatal OPE exposure on executive function (EF) in preschoolers.
Methods:
We selected 340 preschoolers from the Norwegian Mother, Father, and Child Cohort Study. Diphenyl-phosphate (DPhP), di-n-butyl-phosphate (DnBP), bis(2-butoxyethyl) phosphate (BBOEP), and bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) were measured in maternal urine. EF was measured using the Behavior Rating Inventory of Executive Functioning-Preschool (BRIEF-P) and the Stanford-Binet fifth edition (SB-5). EF scores were scaled so a higher score indicated worse performance. We estimated exposure-outcome associations and evaluated modification by child sex using linear regression.
Results:
Higher DnBP was associated with lower EF scores across multiple rater-based domains. Higher DPhP and BDCIPP were associated with lower SB-5 verbal working memory (β = 0.49, 95% CI = 0.12, 0.87; β = 0.53, 95% CI = 0.08, 1.02), and higher BBOEP was associated with lower teacher-rated inhibition (β = 0.34, 95% CI = 0.01, 0.63). DPhP was associated with lower parent-reported BRIEF-P measures in boys but not girls [inhibition: boys: 0.37 (95% CI = 0.03, 0.93); girls: –0.48 (95% CI = –1.27, 0.19); emotional control: boys: 0.44 (95% CI = –0.13, 1.26); girls: –0.83 (95% CI = –1.73, –0.00); working memory: boys: 0.49 (95% CI = 0.03, 1.08); girls: –0.40 (95% CI = –1.11, 0.36)]. Fewer sex interactions were observed for DnBP, BBOEP, and BDCIPP, with irregular patterns observed across EF domains.
Conclusions:
We found some evidence prenatal OPE exposure may impact EF in preschoolers and variation in associations by sex. | |
dc.language | EN | |
dc.publisher | International Society for Environmental Epidemiology/ Wolters Kluwer | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.title | Prenatal organophosphate ester exposure and executive function in Norwegian preschoolers | |
dc.title.alternative | ENEngelskEnglishPrenatal organophosphate ester exposure and executive function in Norwegian preschoolers | |
dc.type | Journal article | |
dc.creator.author | Hall, Amber M. | |
dc.creator.author | Keil, Alexander P. | |
dc.creator.author | Choi, Giehae | |
dc.creator.author | Ramos, Amanda M. | |
dc.creator.author | Richardson, David B. | |
dc.creator.author | Olshan, Andrew F. | |
dc.creator.author | Martin, Chantel L. | |
dc.creator.author | Villanger, Gro Dehli | |
dc.creator.author | Reichborn-Kjennerud, Ted | |
dc.creator.author | Zeiner, Pål | |
dc.creator.author | Øvergaard, Kristin | |
dc.creator.author | Sakhi, Amrit Kaur | |
dc.creator.author | Thomsen, Cathrine | |
dc.creator.author | Aase, Heidi | |
dc.creator.author | Engel, Stephanie M. | |
cristin.unitcode | 185,17,5,7 | |
cristin.unitname | Helse-, utviklings- og personlighetspsyk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2159490 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental Epidemiology&rft.volume=7&rft.spage=1&rft.date=2023 | |
dc.identifier.jtitle | Environmental Epidemiology | |
dc.identifier.volume | 7 | |
dc.identifier.issue | 3 | |
dc.identifier.doi | https://doi.org/10.1097/EE9.0000000000000251 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2474-7882 | |
dc.type.version | PublishedVersion | |
cristin.articleid | e251 | |