Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1
dc.date.accessioned | 2023-07-06T15:19:32Z | |
dc.date.available | 2023-07-06T15:19:32Z | |
dc.date.created | 2015-07-30T11:19:15Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Cortes, Adrian Pulit, Sara L. Leo, Paul J. Pointon, Jenny J. Robinson, Philip C. Weisman, Michael H. Ward, Michael Gensler, Lianne S. Zhou, Xiaodong Garchon, Henri-Jean Chiocchia, Gilles Nossent, Johannes Lie, Benedicte Alexandra Førre, Øystein Thorleiv Tuomilehto, Jaakko Laiho, Kari Bradbury, Linda A. Elewaut, Dirk Burgos-Vargas, Ruben Stebbings, Simon Appleton, Louise Farrah, Claire Lau, Jonathan Haroon, Nigil Mulero, Juan Blanco, Francisco J. González-Gay, Miguel A. López-Larrea, Carlos Bowness, Paul Gaffney, Karl Gaston, Hill Gladman, Dafna D. Rahman, Proton Maksymowych, Walter P. Crusius, J. Bart A. van der Horst-Bruinsma, Irene E. Valle-Oñate, Raphael Romero-Sánchez, Consuelo Myrnes, Inger Pimentel-Santos, Fernando M. Inman, Robert D. Martin, Javier Breban, Maxime Wordsworth, Bryan Paul Reveille, John D. Evans, David M. de Bakker, Paul I.W. Brown, Matthew A. . Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1. Nature Communications. 2015, 6 | |
dc.identifier.uri | http://hdl.handle.net/10852/102631 | |
dc.description.abstract | Abstract Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive. To better understand the genetic basis of the MHC susceptibility loci, we genotyped 7,264 MHC SNPs in 22,647 AS cases and controls of European descent. We impute SNPs, classical HLA alleles and amino-acid residues within HLA proteins, and tested these for association to AS status. Here we show that in addition to effects due to HLA-B*27 alleles, several other HLA-B alleles also affect susceptibility. After controlling for the associated haplotypes in HLA-B , we observe independent associations with variants in the HLA-A , HLA-DPB1 and HLA-DRB1 loci. We also demonstrate that the ERAP1 SNP rs30187 association is not restricted only to carriers of HLA-B*27 but also found in HLA-B*40:01 carriers independently of HLA-B*27 genotype. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1 | |
dc.title.alternative | ENEngelskEnglishMajor histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1 | |
dc.type | Journal article | |
dc.creator.author | Cortes, Adrian | |
dc.creator.author | Pulit, Sara L. | |
dc.creator.author | Leo, Paul J. | |
dc.creator.author | Pointon, Jenny J. | |
dc.creator.author | Robinson, Philip C. | |
dc.creator.author | Weisman, Michael H. | |
dc.creator.author | Ward, Michael | |
dc.creator.author | Gensler, Lianne S. | |
dc.creator.author | Zhou, Xiaodong | |
dc.creator.author | Garchon, Henri-Jean | |
dc.creator.author | Chiocchia, Gilles | |
dc.creator.author | Nossent, Johannes | |
dc.creator.author | Lie, Benedicte Alexandra | |
dc.creator.author | Førre, Øystein Thorleiv | |
dc.creator.author | Tuomilehto, Jaakko | |
dc.creator.author | Laiho, Kari | |
dc.creator.author | Bradbury, Linda A. | |
dc.creator.author | Elewaut, Dirk | |
dc.creator.author | Burgos-Vargas, Ruben | |
dc.creator.author | Stebbings, Simon | |
dc.creator.author | Appleton, Louise | |
dc.creator.author | Farrah, Claire | |
dc.creator.author | Lau, Jonathan | |
dc.creator.author | Haroon, Nigil | |
dc.creator.author | Mulero, Juan | |
dc.creator.author | Blanco, Francisco J. | |
dc.creator.author | González-Gay, Miguel A. | |
dc.creator.author | López-Larrea, Carlos | |
dc.creator.author | Bowness, Paul | |
dc.creator.author | Gaffney, Karl | |
dc.creator.author | Gaston, Hill | |
dc.creator.author | Gladman, Dafna D. | |
dc.creator.author | Rahman, Proton | |
dc.creator.author | Maksymowych, Walter P. | |
dc.creator.author | Crusius, J. Bart A. | |
dc.creator.author | van der Horst-Bruinsma, Irene E. | |
dc.creator.author | Valle-Oñate, Raphael | |
dc.creator.author | Romero-Sánchez, Consuelo | |
dc.creator.author | Myrnes, Inger | |
dc.creator.author | Pimentel-Santos, Fernando M. | |
dc.creator.author | Inman, Robert D. | |
dc.creator.author | Martin, Javier | |
dc.creator.author | Breban, Maxime | |
dc.creator.author | Wordsworth, Bryan Paul | |
dc.creator.author | Reveille, John D. | |
dc.creator.author | Evans, David M. | |
dc.creator.author | de Bakker, Paul I.W. | |
dc.creator.author | Brown, Matthew A. | |
cristin.unitcode | 185,53,18,10 | |
cristin.unitname | Avdeling for medisinsk genetikk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1255718 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=6&rft.spage=&rft.date=2015 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 6 | |
dc.identifier.issue | 1 | |
dc.identifier.doi | https://doi.org/10.1038/ncomms8146 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.type.version | PublishedVersion | |
cristin.articleid | 7146 |
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