dc.date.accessioned | 2023-05-12T15:13:40Z | |
dc.date.available | 2023-05-12T15:13:40Z | |
dc.date.created | 2023-04-17T18:02:09Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Ayorech, Ziada Cheesman, Rosa Catherine Gillespie Eilertsen, Espen Moen Bjørndal, Ludvig Daae Røysamb, Espen McAdams, Tom A. Havdahl, Alexandra Ystrøm, Eivind . Maternal depression and the polygenic p factor: A family perspective on direct and indirect effects. Journal of Affective Disorders. 2023, 332, 159-167 | |
dc.identifier.uri | http://hdl.handle.net/10852/102147 | |
dc.description.abstract | Within-family studies typically assess indirect genetic effects of parents on children, however social support theory points to a critical role of partners and children on women's depression. To address this research gap and account for the high heterogeneity of depression, we calculated a general psychiatric factor using eleven major psychiatric polygenic scores (polygenic p), in up to 25,000 parent-offspring trios from the Norwegian Mother, Father and Child Cohort Study (MoBa). Multilevel modeling of trio polygenic p was used to distinguish direct and indirect genetic effects on mothers depression during pregnancy (gestational age 17 and 30 weeks), infancy (6 months, 18 months) and early childhood (3 years, 5 years, and 8 years). We found mothers polygenic p predicts their depression symptoms (b = 0.092; 95 % CI [0.087,0.098]), outperforming prediction using a single major depressive disorder polygenic score (b = 0.070, 95 % CI [0.066,0.075]). Jointly modeling trio polygenic p revealed indirect genetic effects of fathers (b = 0.022, 95 % CI [0.014,0.030]) and children (b = 0.021, 95 % CI [0.010,0.037]) on mothers' depression. Our results support the generalizability of polygenic effects across mental health and highlight the role of close family members on women's depression. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Maternal depression and the polygenic p factor: A family perspective on direct and indirect effects | |
dc.title.alternative | ENEngelskEnglishMaternal depression and the polygenic p factor: A family perspective on direct and indirect effects | |
dc.type | Journal article | |
dc.creator.author | Ayorech, Ziada | |
dc.creator.author | Cheesman, Rosa Catherine Gillespie | |
dc.creator.author | Eilertsen, Espen Moen | |
dc.creator.author | Bjørndal, Ludvig Daae | |
dc.creator.author | Røysamb, Espen | |
dc.creator.author | McAdams, Tom A. | |
dc.creator.author | Havdahl, Alexandra | |
dc.creator.author | Ystrøm, Eivind | |
cristin.unitcode | 185,17,5,7 | |
cristin.unitname | Helse-, utviklings- og personlighetspsyk | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2141400 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal of Affective Disorders&rft.volume=332&rft.spage=159&rft.date=2023 | |
dc.identifier.jtitle | Journal of Affective Disorders | |
dc.identifier.volume | 332 | |
dc.identifier.startpage | 159 | |
dc.identifier.endpage | 167 | |
dc.identifier.doi | https://doi.org/10.1016/j.jad.2023.03.043 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0165-0327 | |
dc.type.version | PublishedVersion | |
dc.relation.project | EC/H2020/894675 | |
dc.relation.project | NFR/223273 | |
dc.relation.project | NFR/229624 | |