dc.date.accessioned | 2023-03-22T16:15:32Z | |
dc.date.available | 2023-03-22T16:15:32Z | |
dc.date.created | 2023-02-22T09:36:10Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Sikkeland, Jørgen Ng, Matthew Nenseth, Hatice Zeynep Ünal, Bilal Qu, Su Jin, Yang Simonsen, Anne Gjøen Saatcioglu, Fahri . STAMP2 suppresses autophagy in prostate cancer cells by modulating the integrated stress response pathway. American Journal of Cancer Research. 2022, 12(1), 327-336 | |
dc.identifier.uri | http://hdl.handle.net/10852/101721 | |
dc.description.abstract | Six Transmembrane Protein of Prostate 2 (STAMP2) is critical for prostate cancer (PCa) growth. We previously showed that STAMP2 regulates the expression of stress induced transcription factor ATF4, which is implicated in starvation-induced autophagy. We therefore investigated whether STAMP2 is involved in the regulation of autophagy in PCa cells. Here we show that STAMP2 suppresses autophagy in PCa cells through modulation of the integrated stress response axis. We also find that STAMP2 regulates mitochondrial respiration. These findings suggest that STAMP2 has significant metabolic effects through mitochondrial function and autophagy, both of which support PCa growth. | |
dc.language | EN | |
dc.title | STAMP2 suppresses autophagy in prostate cancer cells by modulating the integrated stress response pathway | |
dc.title.alternative | ENEngelskEnglishSTAMP2 suppresses autophagy in prostate cancer cells by modulating the integrated stress response pathway | |
dc.type | Journal article | |
dc.creator.author | Sikkeland, Jørgen | |
dc.creator.author | Ng, Matthew | |
dc.creator.author | Nenseth, Hatice Zeynep | |
dc.creator.author | Ünal, Bilal | |
dc.creator.author | Qu, Su | |
dc.creator.author | Jin, Yang | |
dc.creator.author | Simonsen, Anne Gjøen | |
dc.creator.author | Saatcioglu, Fahri | |
cristin.unitcode | 185,15,29,40 | |
cristin.unitname | Seksjon for biokjemi og molekylærbiologi | |
cristin.ispublished | true | |
cristin.fulltext | postprint | |
cristin.qualitycode | 1 | |
dc.identifier.cristin | 2128083 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American Journal of Cancer Research&rft.volume=12&rft.spage=327&rft.date=2022 | |
dc.identifier.jtitle | American Journal of Cancer Research | |
dc.identifier.volume | 12 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 327 | |
dc.identifier.endpage | 336 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2156-6976 | |
dc.type.version | AcceptedVersion | |