dc.date.accessioned | 2023-03-15T16:13:48Z | |
dc.date.available | 2023-03-15T16:13:48Z | |
dc.date.created | 2022-08-04T15:14:00Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Pekec, Tina Lewandowski, Jarosław Komur, Alicja Sobańska, Daria Guo, Yanwu Świtońska-Kurkowska, Karolina Malecki, Jedrzej Mieczyslaw Dubey, Abhishek Pokrzywa, Wojciech Frankowski, Marcin Figiel, Maciej Ciosk, Rafal . Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons. Nature Communications. 2022, 13(1) | |
dc.identifier.uri | http://hdl.handle.net/10852/101492 | |
dc.description.abstract | Abstract How animals rewire cellular programs to survive cold is a fascinating problem with potential biomedical implications, ranging from emergency medicine to space travel. Studying a hibernation-like response in the free-living nematode Caenorhabditis elegans , we uncovered a regulatory axis that enhances the natural resistance of nematodes to severe cold. This axis involves conserved transcription factors, DAF-16/FoxO and PQM-1, which jointly promote cold survival by upregulating FTN-1, a protein related to mammalian ferritin heavy chain (FTH1). Moreover, we show that inducing expression of FTH1 also promotes cold survival of mammalian neurons, a cell type particularly sensitive to deterioration in hypothermia. Our findings in both animals and cells suggest that FTN-1/FTH1 facilitates cold survival by detoxifying ROS-generating iron species. We finally show that mimicking the effects of FTN-1/FTH1 with drugs protects neurons from cold-induced degeneration, opening a potential avenue to improved treatments of hypothermia. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Ferritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons | |
dc.title.alternative | ENEngelskEnglishFerritin-mediated iron detoxification promotes hypothermia survival in Caenorhabditis elegans and murine neurons | |
dc.type | Journal article | |
dc.creator.author | Pekec, Tina | |
dc.creator.author | Lewandowski, Jarosław | |
dc.creator.author | Komur, Alicja | |
dc.creator.author | Sobańska, Daria | |
dc.creator.author | Guo, Yanwu | |
dc.creator.author | Świtońska-Kurkowska, Karolina | |
dc.creator.author | Malecki, Jedrzej Mieczyslaw | |
dc.creator.author | Dubey, Abhishek | |
dc.creator.author | Pokrzywa, Wojciech | |
dc.creator.author | Frankowski, Marcin | |
dc.creator.author | Figiel, Maciej | |
dc.creator.author | Ciosk, Rafal | |
cristin.unitcode | 185,15,29,40 | |
cristin.unitname | Seksjon for biokjemi og molekylærbiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2041237 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature Communications&rft.volume=13&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Nature Communications | |
dc.identifier.volume | 13 | |
dc.identifier.issue | 1 | |
dc.identifier.pagecount | 19 | |
dc.identifier.doi | https://doi.org/10.1038/s41467-022-32500-z | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 2041-1723 | |
dc.type.version | PublishedVersion | |
cristin.articleid | 4883 | |
dc.relation.project | NFR/286499 | |