dc.date.accessioned | 2023-03-15T16:10:30Z | |
dc.date.available | 2023-03-15T16:10:30Z | |
dc.date.created | 2022-08-04T14:57:32Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Sobańska, Daria Komur, Alicja Chabowska-Kita, Agnieszka Gumna, Julita Kumari, Pooja Pachulska-Wieczorek, Katarzyna Ciosk, Rafal . The silencing of ets-4 mRNA relies on the functional cooperation between REGE-1/Regnase-1 and RLE-1/Roquin-1. Nucleic Acids Research (NAR). 2022, 50(14), 8226-8239 | |
dc.identifier.uri | http://hdl.handle.net/10852/101489 | |
dc.description.abstract | Abstract
Regnase-1 is an evolutionarily conserved endoribonuclease. It degrades diverse mRNAs important for many biological processes including immune homeostasis, development and cancer. There are two competing models of Regnase-1-mediated mRNA silencing. One model postulates that Regnase-1 works together with another RNA-binding protein, Roquin-1, which recruits Regnase-1 to specific mRNAs. The other model proposes that the two proteins function separately. Studying REGE-1, the Caenorhabditis elegans ortholog of Regnase-1, we have uncovered its functional relationship with RLE-1, the nematode counterpart of Roquin-1. While both proteins are essential for mRNA silencing, REGE-1 and RLE-1 appear to associate with target mRNA independently of each other. Thus, although the functional interdependence between REGE-1/Regnase-1 and RLE-1/Roquin-1 is conserved, the underlying mechanisms may display species-specific variation, providing a rare perspective on the evolution of this important post-transcriptional regulatory mechanism. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | The silencing of ets-4 mRNA relies on the functional cooperation between REGE-1/Regnase-1 and RLE-1/Roquin-1 | |
dc.title.alternative | ENEngelskEnglishThe silencing of ets-4 mRNA relies on the functional cooperation between REGE-1/Regnase-1 and RLE-1/Roquin-1 | |
dc.type | Journal article | |
dc.creator.author | Sobańska, Daria | |
dc.creator.author | Komur, Alicja | |
dc.creator.author | Chabowska-Kita, Agnieszka | |
dc.creator.author | Gumna, Julita | |
dc.creator.author | Kumari, Pooja | |
dc.creator.author | Pachulska-Wieczorek, Katarzyna | |
dc.creator.author | Ciosk, Rafal | |
cristin.unitcode | 185,15,29,40 | |
cristin.unitname | Seksjon for biokjemi og molekylærbiologi | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2041228 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nucleic Acids Research (NAR)&rft.volume=50&rft.spage=8226&rft.date=2022 | |
dc.identifier.jtitle | Nucleic Acids Research (NAR) | |
dc.identifier.volume | 50 | |
dc.identifier.issue | 14 | |
dc.identifier.startpage | 8226 | |
dc.identifier.endpage | 8239 | |
dc.identifier.doi | https://doi.org/10.1093/nar/gkac609 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 0305-1048 | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/286499 | |