Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years
dc.date.accessioned | 2023-02-27T18:31:15Z | |
dc.date.available | 2023-02-27T18:31:15Z | |
dc.date.created | 2021-09-19T09:35:28Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Dima, Danai Modabbernia, Amirhossein Papachristou, Efstathios Doucet, Gaëlle E. Agartz, Ingrid Aghajani, Moji Akudjedu, Theophilus N. Albajes-Eizagirre, Anton Alnæs, Dag Alpert, Kathryn I. Andersson, Micael Andreasen, Nancy C. Andreassen, Ole Asherson, Philip Banaschewski, Tobias Bargallo, Nuria Baumeister, Sarah Baur-Streubel, Ramona Bertolino, Alessandro Bonvino, Aurora Boomsma, Dorret I Borgwardt, Stefan Bourque, Josiane Brandeis, Daniel Breier, Alan Brodaty, Henry Brouwer, Rachel M. Buitelaar, Jan K. Busatto, Geraldo F. Buckner, Randy L. Calhoun, Vincent Canales-Rodriguez, Erick J. Cannon, Dara M. Caseras, Xavier Castellanos, Francisco X. Cervenka, Simon Chaim-Avancini, Tiffany M. Ching, Christopher R. K. Chubar, Victoria Clark, Vincent P. Conrod, Patricia Conzelmann, Annette Crespo-Facorro, Benedicto Crivello, Fabrice Doan, Nhat Trung Dørum, Erlend Solberg Espeseth, Thomas Jönsson, Erik Gunnar Nordvik, Jan Egil Nyberg, Lars Tamnes, Christian Krog Westlye, Lars Tjelta . Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years. Human Brain Mapping. 2022, 43(1)-452 | |
dc.identifier.uri | http://hdl.handle.net/10852/100464 | |
dc.description.abstract | Age has a major effect on brain volume. However, the normative studies available are constrained by small sample sizes, restricted age coverage and significant methodological variability. These limitations introduce inconsistencies and may obscure or distort the lifespan trajectories of brain morphometry. In response, we capitalized on the resources of the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) Consortium to examine age-related trajectories inferred from cross-sectional measures of the ventricles, the basal ganglia (caudate, putamen, pallidum, and nucleus accumbens), the thalamus, hippocampus and amygdala using magnetic resonance imaging data obtained from 18,605 individuals aged 3–90 years. All subcortical structure volumes were at their maximum value early in life. The volume of the basal ganglia showed a monotonic negative association with age thereafter; there was no significant association between age and the volumes of the thalamus, amygdala and the hippocampus (with some degree of decline in thalamus) until the sixth decade of life after which they also showed a steep negative association with age. The lateral ventricles showed continuous enlargement throughout the lifespan. Age was positively associated with inter-individual variability in the hippocampus and amygdala and the lateral ventricles. These results were robust to potential confounders and could be used to examine the functional significance of deviations from typical age-related morphometric patterns. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years | |
dc.title.alternative | ENEngelskEnglishSubcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3–90 years | |
dc.type | Journal article | |
dc.creator.author | Dima, Danai | |
dc.creator.author | Modabbernia, Amirhossein | |
dc.creator.author | Papachristou, Efstathios | |
dc.creator.author | Doucet, Gaëlle E. | |
dc.creator.author | Agartz, Ingrid | |
dc.creator.author | Aghajani, Moji | |
dc.creator.author | Akudjedu, Theophilus N. | |
dc.creator.author | Albajes-Eizagirre, Anton | |
dc.creator.author | Alnæs, Dag | |
dc.creator.author | Alpert, Kathryn I. | |
dc.creator.author | Andersson, Micael | |
dc.creator.author | Andreasen, Nancy C. | |
dc.creator.author | Andreassen, Ole | |
dc.creator.author | Asherson, Philip | |
dc.creator.author | Banaschewski, Tobias | |
dc.creator.author | Bargallo, Nuria | |
dc.creator.author | Baumeister, Sarah | |
dc.creator.author | Baur-Streubel, Ramona | |
dc.creator.author | Bertolino, Alessandro | |
dc.creator.author | Bonvino, Aurora | |
dc.creator.author | Boomsma, Dorret I | |
dc.creator.author | Borgwardt, Stefan | |
dc.creator.author | Bourque, Josiane | |
dc.creator.author | Brandeis, Daniel | |
dc.creator.author | Breier, Alan | |
dc.creator.author | Brodaty, Henry | |
dc.creator.author | Brouwer, Rachel M. | |
dc.creator.author | Buitelaar, Jan K. | |
dc.creator.author | Busatto, Geraldo F. | |
dc.creator.author | Buckner, Randy L. | |
dc.creator.author | Calhoun, Vincent | |
dc.creator.author | Canales-Rodriguez, Erick J. | |
dc.creator.author | Cannon, Dara M. | |
dc.creator.author | Caseras, Xavier | |
dc.creator.author | Castellanos, Francisco X. | |
dc.creator.author | Cervenka, Simon | |
dc.creator.author | Chaim-Avancini, Tiffany M. | |
dc.creator.author | Ching, Christopher R. K. | |
dc.creator.author | Chubar, Victoria | |
dc.creator.author | Clark, Vincent P. | |
dc.creator.author | Conrod, Patricia | |
dc.creator.author | Conzelmann, Annette | |
dc.creator.author | Crespo-Facorro, Benedicto | |
dc.creator.author | Crivello, Fabrice | |
dc.creator.author | Doan, Nhat Trung | |
dc.creator.author | Dørum, Erlend Solberg | |
dc.creator.author | Espeseth, Thomas | |
dc.creator.author | Jönsson, Erik Gunnar | |
dc.creator.author | Nordvik, Jan Egil | |
dc.creator.author | Nyberg, Lars | |
dc.creator.author | Tamnes, Christian Krog | |
dc.creator.author | Westlye, Lars Tjelta | |
cristin.unitcode | 185,53,10,11 | |
cristin.unitname | Senter for psykoseforskning | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 1935635 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Human Brain Mapping&rft.volume=43&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Human Brain Mapping | |
dc.identifier.volume | 43 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 452 | |
dc.identifier.endpage | 469 | |
dc.identifier.doi | https://doi.org/10.1002/hbm.25320 | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1065-9471 | |
dc.type.version | PublishedVersion | |
dc.relation.project | NFR/323951 | |
dc.relation.project | NFR/223273 | |
dc.relation.project | NFR/288083 |
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