dc.date.accessioned | 2023-02-20T16:40:52Z | |
dc.date.available | 2023-02-20T16:40:52Z | |
dc.date.created | 2023-01-04T13:07:19Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Sæther, Linn Sofie Ueland, Thor Haatveit, Beathe Maglanoc, Luigi Szabo, Attila Djurovic, Srdjan Aukrust, Pål Roelfs, Daniël Ormerod, Monica Bettina E. Greenwood Lagerberg, Trine Vik Steen, Nils Eiel Melle, Ingrid Andreassen, Ole Ueland, Torill . Inflammation and cognition in severe mental illness: patterns of covariation and subgroups. Molecular Psychiatry. 2022 | |
dc.identifier.uri | http://hdl.handle.net/10852/100206 | |
dc.description.abstract | Abstract A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses (SMI), such as schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, multivariate relationships between peripheral inflammatory/immune-related markers and cognitive domains are unclear, and many studies do not account for inter-individual variance in both cognitive functioning and inflammatory/immune status. This study aimed to investigate covariance patterns between inflammatory/immune-related markers and cognitive domains and further elucidate heterogeneity in a large SMI and healthy control (HC) cohort (SZ = 343, BD = 289, HC = 770). We applied canonical correlation analysis (CCA) to identify modes of maximum covariation between a comprehensive selection of cognitive domains and inflammatory/immune markers. We found that poor verbal learning and psychomotor processing speed was associated with higher levels of interleukin-18 system cytokines and beta defensin 2, reflecting enhanced activation of innate immunity, a pattern augmented in SMI compared to HC. Applying hierarchical clustering on covariance patterns identified by the CCA revealed a high cognition—low immune dysregulation subgroup with predominantly HC (24% SZ, 45% BD, 74% HC) and a low cognition—high immune dysregulation subgroup predominantly consisting of SMI patients (76% SZ, 55% BD, 26% HC). These subgroups differed in IQ, years of education, age, CRP, BMI (all groups), level of functioning, symptoms and defined daily dose (DDD) of antipsychotics (SMI cohort). Our findings suggest a link between cognitive impairment and innate immune dysregulation in a subset of individuals with severe mental illness. | |
dc.language | EN | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Inflammation and cognition in severe mental illness: patterns of covariation and subgroups | |
dc.title.alternative | ENEngelskEnglishInflammation and cognition in severe mental illness: patterns of covariation and subgroups | |
dc.type | Journal article | |
dc.creator.author | Sæther, Linn Sofie | |
dc.creator.author | Ueland, Thor | |
dc.creator.author | Haatveit, Beathe | |
dc.creator.author | Maglanoc, Luigi | |
dc.creator.author | Szabo, Attila | |
dc.creator.author | Djurovic, Srdjan | |
dc.creator.author | Aukrust, Pål | |
dc.creator.author | Roelfs, Daniël | |
dc.creator.author | Ormerod, Monica Bettina E. Greenwood | |
dc.creator.author | Lagerberg, Trine Vik | |
dc.creator.author | Steen, Nils Eiel | |
dc.creator.author | Melle, Ingrid | |
dc.creator.author | Andreassen, Ole | |
dc.creator.author | Ueland, Torill | |
cristin.unitcode | 185,17,5,0 | |
cristin.unitname | Psykologisk institutt | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |
dc.identifier.cristin | 2100500 | |
dc.identifier.bibliographiccitation | info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular Psychiatry&rft.volume=&rft.spage=&rft.date=2022 | |
dc.identifier.jtitle | Molecular Psychiatry | |
dc.identifier.volume | 28 | |
dc.identifier.startpage | 1284 | |
dc.identifier.endpage | 1292 | |
dc.identifier.doi | https://doi.org/10.1038/s41380-022-01924-w | |
dc.type.document | Tidsskriftartikkel | |
dc.type.peerreviewed | Peer reviewed | |
dc.source.issn | 1359-4184 | |
dc.type.version | PublishedVersion | |
dc.relation.project | SIGMA2/NS9666S | |
dc.relation.project | HSØ/2020089 | |
dc.relation.project | NFR/223273 | |