Browsing Det matematisk-naturvitenskapelige fakultet by Author "Haabeth, Ole Audun"

Now showing items 1-4 of 4

  • B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells 
    Huszthy, Peter Csaba; Gopalakrishnan, Ramakrishna Prabhu; Jacobsen, Johanne Tracey; Haabeth, Ole Audun; Løset, Geir Åge; Braathen, Ranveig; Schenck, Karl; Tveita, Anders Aune; Munthe, Ludvig Andre; Bogen, Bjarne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    The B cell receptors (BCRs) for antigen express variable (V) regions that are enormously diverse, thus serving as markers on individual B cells. V region-derived idiotypic (Id) peptides can be displayed as pId:MHCII complexes ...
  • CD4+ T-cell killing of multiple myeloma cells is mediated by resident bone marrow macrophages 
    Haabeth, Ole Audun; Hennig, Kjartan; Fauskanger, Marte; Løset, Geir Åge; Bogen, Bjarne; Tveita, Anders Aune (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
    Abstract CD4+ T cells may induce potent antitumor immune responses through interaction with antigen-presenting cells within the tumor microenvironment. Using a murine model of multiple myeloma, we demonstrated ...
  • How do CD4+ T cells detect and eliminate tumor cells that either lack or express MHC class II molecules? 
    Haabeth, Ole Audun; Tveita, Anders; Fauskanger, Marte Hotvedt; Schjesvold, Fredrik Hellem; Lorvik, Kristina Berg; Hofgaard, Peter Olaf; Omholt, Hilde; Munthe, Ludvig Andre; Dembic, Zlatko; Corthay, Alexandre; Bogen, Bjarne (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2014)
    CD4+ T cells contribute to tumor eradication, even in the absence of CD8+ T cells. Cytotoxic CD4+ T cells can directly kill MHC class II positive tumor cells. More surprisingly, CD4+ T cells can indirectly eliminate tumor ...
  • Tumor killing by CD4+ T cells is mediated via induction of inducible nitric oxide synthase-dependent macrophage cytotoxicity 
    Fauskanger, Marte; Haabeth, Ole Audun; Skjeldal, Frode Miltzow; Bogen, Bjarne; Tveita, Anders (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    CD4+ T cells can induce potent anti-tumor immune responses. Due to the lack of MHC class II expression in most cancer cells, antigen recognition occurs indirectly via uptake and presentation on tumor-infiltrating ...