Finn forfatter "Høydahl, Lene Støkken"

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  • A high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation 
    Frick, Rahel; Høydahl, Lene Støkken; Petersen, Jan; du Pré, Fleur; Kumari, Shraddha; Berntsen, Grete; Dewan, Alisa Elinsdatter; Jeliazkov, Jeliazko R.; Gunnarsen, Kristin Støen; Frigstad, Terje; Vik, Erik S.; Llerena, Carmen; Lundin, Knut; Yaqub, Sheraz; Jahnsen, Jørgen; Gray, Jeffrey J.; Rossjohn, Jamie; Sollid, Ludvig Magne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2021)
    Antibodies specific for peptides bound to human leukocyte antigen (HLA) molecules are valuable tools for studies of antigen presentation and may have therapeutic potential. Here, we generated human T cell receptor (TCR)–like ...
  • A TRAV26-1-encoded recognition motif focuses the biased T cell response in celiac disease 
    Frick, Rahel; Gunnarsen, Kristin Støen; Dahal-Koirala, Shiva; Risnes, Louise Fremgaard; Sollid, Ludvig Magne; Sandlie, Inger; Høydahl, Lene Støkken; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2020)
  • Affinity maturation of TCR-like antibodies using phage display guided by structural modeling 
    Frick, Rahel; Høydahl, Lene Støkken; Hodnebrug, Ina; Vik, Erik Sebastian; Dalhus, Bjørn; Sollid, Ludvig Magne; Gray, Jeffrey J; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract TCR-like antibodies represent a unique type of engineered antibodies with specificity toward pHLA, a ligand normally restricted to the sensitive recognition by T cells. Here, we report a phage display-based ...
  • Biophysical differences in IgG1 Fc-based therapeutics relate to their cellular handling, interaction with FcRn and plasma half-life 
    Tollefsrud Gjølberg, Torleif; Frick, Rahel; Mester, Simone; Foss, Stian; Grevys, Algirdas; Høydahl, Lene Støkken; Jørstad, Øystein Kalsnes; Schlothauer, Tilman; Sandlie, Inger; Moe, Morten Carsten; Andersen, Jan Terje (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2022)
    Abstract Antibody-based therapeutics (ABTs) are used to treat a range of diseases. Most ABTs are either full-length IgG1 antibodies or fusions between for instance antigen (Ag)-binding receptor domains and the IgG1 Fc ...
  • Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour- specificity through an unusual H-chain CDR3 architecture 
    Bjerregaard-Andersen, Kaare; Johannesen, Hedda; Abdel-Rahman, Noha Mansour Hassan; Heggelund, Julie Elisabeth; Hoås, Helene Mykland; Abraha, Fana; Bousquet, Paula; Høydahl, Lene Støkken; Burschowsky, Daniel; Rojas, Gertrudis; Oscarson, Stefan; Løset, Geir Åge; Krengel, Ute (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    Targeted cancer immunotherapy offers increased efficacy concomitantly with reduced side effects. One antibody with promising clinical potential is 14F7, which specifically recognises the NeuGc GM3 ganglioside. This antigen ...
  • Multivalent pIX phage display selects for distinct and improved antibody properties 
    Høydahl, Lene Støkken; Nilssen, Nicolay Rustad; Gunnarsen, Kristin Støen; du Pré, Marie Fleur; Iversen, Rasmus; Roos, Norbert; Chen, Xi; Michaelsen, Terje Einar; Sollid, Ludvig Magne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2016)
    Phage display screening readily allows for the identification of a multitude of antibody specificities, but to identify optimal lead candidates remains a challenge. Here, we direct the antibody-capsid fusion away from the ...
  • Plasma Cells Are the Most Abundant Gluten Peptide MHC-expressing Cells in Inflamed Intestinal Tissues From Patients With Celiac Disease 
    Høydahl, Lene Støkken; Richter, Lisa Maria; Frick, Rahel; Snir, Omri; Gunnarsen, Kristin Støen; Landsverk, Ole J. B.; Iversen, Rasmus; Jeliazkov, Jeliazko R.; Gray, Jeffrey J.; Bergseng, Elin; Foss, Stian; Qiao, Shuo Wang; Lundin, Knut Erik Aslaksen; Jahnsen, Jørgen; Jahnsen, Frode Lars; Sandlie, Inger; Sollid, Ludvig Magne; Løset, Geir Åge (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Background & Aims Development of celiac disease is believed to involve the transglutaminase-dependent response of CD4+ T cells toward deamidated gluten peptides in the intestinal mucosa of individuals with specific ...
  • Soluble T-cell receptor design influences functional yield in an E. coli chaperone-assisted expression system 
    Gunnarsen, Kristin Støen; Høydahl, Lene Støkken; Neumann, Ralf Stefan; Bjerregaard-Andersen, Kaare; Nilssen, Nicolay Rustad; Sollid, Ludvig Magne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2018)
    There is a quest for production of soluble protein of high quality for the study of T-cell receptors (TCRs), but expression often results in low yields of functional molecules. In this study, we used an E. coli chaperone-assisted ...
  • Targeting the MHC Ligandome by Use of TCR-Like Antibodies 
    Høydahl, Lene Støkken; Frick, Rahel; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2019)
    Monoclonal antibodies (mAbs) are valuable as research reagents, in diagnosis and in therapy. Their high specificity, the ease in production, favorable biophysical properties and the opportunity to engineer different ...
  • A TCRα framework–centered codon shapes a biased T cell repertoire through direct MHC and CDR3β interactions 
    Gunnarsen, Kristin Støen; Høydahl, Lene Støkken; Risnes, Louise Fremgaard; Dahal-Koirala, Shiva; Neumann, Ralf Stefan; Bergseng, Elin; Frigstad, Terje; Frick, Rahel; du Pré, Marie Fleur; Dalhus, Bjørn; Lundin, Knut Erik Aslaksen; Qiao, Shuo Wang; Sollid, Ludvig Magne; Sandlie, Inger; Løset, Geir Åge (Journal article / Tidsskriftartikkel / PublishedVersion; Peer reviewed, 2017)
    Selection of biased T cell receptor (TCR) repertoires across individuals is seen in both infectious diseases and autoimmunity, but the underlying molecular basis leading to these shared repertoires remains unclear. Celiac ...