Browsing by Author "Yu, Shimin"

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  • Potent 5-Cyano-6-phenyl-pyrimidin-based derivatives targeting DCN1-UBE2M interaction 
    Zhou, Wenjuan; Ma, Liying; Ding, Lina; Guo, Qian; He, Zhangxu; Yang, Jing; Qiao, Hui; Li, Lingyu; Yang, Jie; Yu, Shimin; Zhao, Lili; Wang, Shaomeng; Liu, Hong-Min; Suo, Zhenhe; Zhao, Wen (Journal article / Tidsskriftartikkel / AcceptedVersion; Peer reviewed, 2019)
    Neddylation of the Cullin-RING E3 ligases (CRLs) regulates the homeostasis of approximately 20% of cellular proteins. Defective in cullin neddylation 1 (DCN1), as a co-E3 ligase, interacts with UBE2M to enhance the activation ...